1887
Volume 2012, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Immune thrombocytopenic purpura (UP) is a common pediatric hematologic disorder. Bone marrow aspiration (BMA) is often performed in children with acute ITP to rule out leukemia, aplastic anemia or other hematologic diseases. However, whether BMA is needed in children with typical and hematological features of acute ITP has been questioned. To determine whether BMA is indicated in acute childhood ITP, samples were examined from 122 patients with the provisional diagnosis of acute ITP attending Hevi Pediatric Teaching Hospital, Duhok/North of Iraq between August 2006 and July 2010. Typical acute ITP was defined as an appearance of well being, no hepatosplenomegaly, no lymphadenopathy, normal Hb, WBC, neutrophil count and peripheral blood smear except for thrombocytopenia. A platelet count of 50 x109/L or lower was the cut-off level. No diagnoses of leukemia or aplastic anemia were revealed in the 122 (100%) children with typical hematologic features of ITP and it was concluded that routine BMA is not needed for children with typical features of acute ITP.

Loading

Article metrics loading...

/content/journals/10.5339/qmj.2012.1.14
2012-06-01
2024-04-19
Loading full text...

Full text loading...

References

  1. Karpatkin S. Autoimmune (idiopathic) thrombocytopenic purpura. Lancet. 1997; 349::15311536.
    [Google Scholar]
  2. Sutor AH, Harms A, Kaufmehl K. Acute immune thrombocytopenia (ITP) in childhood: Retrospective and prospective survey in Germany. Semin Thromb Hemost. 2001; 27:3:253267.
    [Google Scholar]
  3. Zeller B, Helgestad J, Hellebostad M, et al., Immune thrombocytopenic purpura in childhood in Norway: A prospective, population-based registration. Pediatr Hematol Oncol. 2000; 17:7:551558.
    [Google Scholar]
  4. Kuhne T, Imbach P, Bolton-Maggs PH, et al., Newly diagnosed idiopathic thrombocytopenic purpura in childhood: An observational study. Lancet. 2001; 358:9299:21222125.
    [Google Scholar]
  5. Blanchette VS, Carcao M. Childhood acute immune thrombocytopenic purpura: 20 years later (review). Semin Thromb Hemost. 2003; 29::605617.
    [Google Scholar]
  6. Buchanan GR. Thrombocytopenia during childhood: What the pediatrician needs to know. Pediatr Rev. 2005; 26::401409.
    [Google Scholar]
  7. Tarantino M. The treatment of immune thrombocytopenic purpura in children. Curr Hematol Rep. 2006; 5::8994.
    [Google Scholar]
  8. Chandra J, Ravi R, Singh V, Narayan S, Sharma S, Dutta AK. Bleeding manifestations in severely thrombocytopenic children with immune thrombocytopenic purpura. Hematology. 2006; 11::131133.
    [Google Scholar]
  9. Jadavji T, Scheifele D, Halperin S. Thrombocytopenia after immunization of Canadian children, 1992 to 2001. Pediatr Infect Dis J. 2003; 22::119122.
    [Google Scholar]
  10. George JN, et al., Idiopathic thrombocytopenic purpura: A practice guideline developed by explicit methods for the American Society of Hematology. Blood. 1996; 88::340.
    [Google Scholar]
  11. Lilleyman JS. Chronic idiopathic thrombocytopenic purpura: The pediatrician's dilemma. Pediatr Hematol Oncol. 1990; 7::115118.
    [Google Scholar]
  12. Robb LG, Tiedeman K. Idiopathic thrombocytopenic purpura: Predictors of chronic disease. Arch Dis Child. 1990; 65::502507.
    [Google Scholar]
  13. Hathaway W. Idiopathic thrombocytopenic purpura. In: Rudolph AHoffman J, eds. Pediatrics. Norwalk, CT: Appleton Century Crofts 1982;:11151116.
    [Google Scholar]
  14. McMillan C. Platelet and vascular disorders. In: Miller DBalhner RMcMillan C, eds. Blood Diseases in Infancy and Childhood. St Louis, MO: CVMosby Co 1984;:795806.
    [Google Scholar]
  15. Schulman I. Diagnosis and treatment: Management of idiopathic thrombocytopenia purpura. Pediatrics. 1964; 33::979980.
    [Google Scholar]
  16. Stuart M, McKenna R. The platelet and vasculature. In: Nathan DOski F, eds. Hematology of Infancy and Childhood. Philadelphia, PA: WB Saunders 1981;:12401241.
    [Google Scholar]
  17. Cohen H, Lipton J. Blood disorders. In: Graef JCone T, eds. Manual of Pediatric Therapeutics. Boston, MA: Little Brown & Co 1980;:440441.
    [Google Scholar]
  18. Buchanan G. Childhood acute idiopathic thrombocytopenic purpura: How many tests and how much treatment required? J Pediatr. 1985; 106::928930.
    [Google Scholar]
  19. Du ban sky S, Oski F. Controversies in the management of acute idiopathic. Megakaryocytopoiesis (review). IntJ Hematol. 2005; 81::9499.
    [Google Scholar]
  20. Mcintosh N. Is bone marrow investigation required in isolated childhood thrombocytopenia? Lancet. 1982; 1::956.
    [Google Scholar]
  21. Dubansky AS, Boyett JM, Fallette J, et al., Isolated Thrombocytopenia in Children With Acute Lymphoblastic Leukemia: A Rare Event in a Pediatric Oncology Group. Pediatrics. 1986; 77::4952.
    [Google Scholar]
  22. Saarinen UM, Wegelius R. Preleukemic syndrome in children. Am J Pediatr Hematol Oncol. 1984; 6::137145.
    [Google Scholar]
  23. Toledano S. Preleukemic phase in childhood acute lymphoblastic leukemia. J Pediatr. 1977; 91::507508.
    [Google Scholar]
  24. Roberts BE, Abbott CR, Fortt RW, et al., Preleukemia: A report of four cases. Acta Hematol. 1968; 39::2028.
    [Google Scholar]
  25. Corrigan JJ. Bone marrow aspiration and idiopathic thrombocytopenic purpura. Am J Dis Child. 1988; 142::487.
    [Google Scholar]
  26.  Webster 'a Ninth New Collegiate Dictionary. Springfield, MA: G&C Merriam 1983:p.285.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2012.1.14
Loading
  • Article Type: Research Article
Keyword(s): bleeding tendencybone marrow aspiration and immune thrombocytopenic purpura
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error