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oa Brugada Syndrome and Anesthesia
- Source: Qatar Medical Journal, Volume 2007, Issue 2, Nov 2007,
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- 01 November 2007
Abstract
Brugada Syndrome is a distinct form of an arrhythmic disease characterized by right bundle branch block an ST segment elevation in the right pericardial leads (VI - V3) of the electrocardiogram (ECG). This syndrome is clinically important because of the high incidence of sudden death by ventricular fibrillation (VF) without any structural heart disease, and is seen especially in the Asian population including Japanese people. Recently, it has been demonstrated that Brugada Syndrome is generally linked to the mutation of the alpha subunit of the sodium channel gene, SCNSA, and the use of certain anti-arrhythmic sodium channel blockers (Class IA au IC) is the sole the Medical intervention which effectively protects patients with Brugada Syndrome from sudden cardiac death.