1887
Volume 2005, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

An old lady with mitral regurgitation, and chronic atrial fibrillation, who was maintained on amiodarone 200 mg daily for five years, presented with fever and confusion due to septicemia and hepatic encephalopathy. Her chest radiograph and chest CT scan showed interstitial infiltrates. Histopathology of transbronchial biopsies suggested amiodarone-induced lung toxicity. The amiodarone was discontinued and the patient showed some improvement. The case, the presentation and the diagnosis are discussed.

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/content/journals/10.5339/qmj.2005.1.21
2005-06-01
2024-04-24
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References

  1. Gosselink ATM, Crijns HJGM, Van Gelder IC, Hillege H, Wiesfeld ACP, Lie KI. Low dose amiodarone for maintenance of sinus rhythm after cardioversion of atrial fibrillation or flutter. JAMA. 1992; 267::32893293.
    [Google Scholar]
  2. Kudenchuk PJ, Pierson BJ, Greene HL, Graham EL, Sears GK, Trobaugh GB. Prospective evaluation of amiodarone pulmonary toxicity. Chest. 1984; 86::541548.
    [Google Scholar]
  3. Dusman RE, Stanton MS, Miles WM, Klein LS, Zipes DP, Fineberg NS, et al., Clinical features of amiodarone-induced pulmonary toxicity. Circulation. 1990; 82::5159.
    [Google Scholar]
  4. Lyle A, Siddoway MD. Amiodarone: Guidelines for Use and Monitoring. Am Earn Physician. 2003; 68::21892196.
    [Google Scholar]
  5. Martin WJ II, Rosenow EC III. Amiodarone pulmonary toxicity: Recognition and pathogenesis; part I. Chest. 1988; 93::10671075.
    [Google Scholar]
  6. Gillian A, Jessurun J, Harry J, Crijns G M. Amiodarone pulmonary toxicity. BMJ. 1997; 314::619.
    [Google Scholar]
  7. Michael C, Ott Andras Khoor, Jack P Leventhal. Pulmonary Toxicity in Patients Receiving Low-Dose Amiodarone. Chest. 2003; 123::646651.
    [Google Scholar]
  8. Edward D Chan, Talmadge E King. Amiodarone pulmonary toxicity. Up-To-Date 11.1.
  9. Dean PJ, Groshart KD, Porterfield JG, et al., Amiodaroneassociated pulmonary toxicity. A clinical and pathologic study of eleven cases. Am J Clin Pathol. 1987; 87::7.
    [Google Scholar]
  10. Standertskjold-Nordenstam CG, Wandtke JC, Hood WB Jr, et al., Amiodarone pulmonary toxicity. Chest radiography and CT in asymptomatic patients. Chest. 1985; 88::143.
    [Google Scholar]
  11. Coudert B, Bailly F, Lombard JN, et al., Amiodarone pneumonitis. Bronchoalveolar lavage findings in 15 patients and review of the literature. Chest. 1992; 102::1005.
    [Google Scholar]
  12. Ohar JA, Jackson F, Dettenmeier PA, et al., Bronchoalveolar lavage cell count and differential are not reliable indicators of amiodarone-induced pneumonitis. Chest. 1992; 102::999.
    [Google Scholar]
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  • Article Type: Case Report
Keyword(s): Amiodarone and pulmonary toxicity
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