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Volume 2012, Issue 1
  • ISSN: 2305-7823
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Abstract

Abstract

Heart failure with preserved ejection fraction (HFpEF) has recently emerged as a major cause of cardiovascular morbidity and mortality. Contrary to initial beliefs, HFpEF is now known to be as common as heart failure with reduced ejection fraction (HFrEF) and carries an unacceptably high mortality rate. With a prevalence that has been steadily rising over the past two decades, it is very likely that HFpEF will represent the dominant heart failure phenotype over the coming few years. The scarcity of trials in this semi-discrete form of heart failure and lack of unified enrolment criteria in the studies conducted to date might have contributed to the current absence of specific therapies. Understanding the epidemiological, pathophysiological and molecular differences (and similarities) between these two forms of heart failure is cornerstone to the development of targeted therapies. Carefully designed studies that adhere to unified diagnostic criteria with the recruitment of appropriate controls and adoption of practical end-points are urgently needed to help identify effective treatment strategies.

© 2012 ElGuindy and Yacoub, licensee Bloomsbury Qatar Foundation Journals.
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2012-07-17
2024-04-25
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Heart failure with preserved ejection fraction
Global Cardiology Science and Practice 2012, 10 (2012); https://doi.org/10.5339/gcsp.2012.10
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  • Article Type: Review Article
Keyword(s): diastolic heart failure, heart failure and heart failure with preserved ejection fraction
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