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Volume 2019, Issue 1
  • EISSN: 2223-506X

Abstract

ABSTRACT

Over the last several decades, obesity and asthma prevalence have risen among children. The increase in overweight and obesity has been associated with an increased risk of asthma in children. Most epidemiological studies have proposed that a high body mass index (BMI) at infancy and early childhood increases the risk of asthma in children. A recently adopted electronic recording system for health service encounters in Primary Health Care Corporation of Qatar has provided a convenient opportunity to assess the possible link between asthma and obesity in children aged 5–12 years.

  1. To calculate the prevalence rate of overweight and obesity among asthmatic children aged 5–12 years using primary health care centers during 2016–2017.
  2. To measure the strength of the association between BMI and asthma in children aged 5–12 years after adjusting for age, gender, and nationality.

This was a case–control study on the electronic health records of children aged 5–12 years who visited one of the primary health care centers during the two-year study period (2016–2017). A total of 9889 children with a diagnosis of asthma and valid BMI measurements were included in the case group, and an identical number of children who visited the health care centers for other reasons and had valid BMI measurements were randomly enrolled in the control group.

The prevalence of obesity (BMI-for-age -score >2) was significantly higher among asthmatics (24.9%) compared with non-asthmatic controls (17.7%). Asthma significantly increased the risk of being obese by 41% in bivariate analysis. The calculated risk estimate for the association between asthma and obesity increased to 70% after adjusting for the confounding effect of age, gender, and nationality.

The present observational study based on a large sample of 5 to 12-year-old children documented a strong association between asthma and obesity (BMI-for-age -score 2 or above). This positive association between asthma and high BMI was stronger among older children, females, and Qatari nationals.

© 2019 [Author(s)], licensee HBKU Press.
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2019-11-30
2024-04-20
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References

  1. Global Asthma Network. The global asthma report 2014. Auckland: Global Asthma Network; 2014[cited 2018 Dec 4]. Available from: http://www.global asthmareport.org/2014/burden/burden.php .
  2. Robertson CF, Roberts MF, Kappers JH. Asthma prevalence in Melbourne schoolchildren: Have we reached the peak? Medical Journal of Australia [Internet]. 2004 Mar 15 [cited 2018 Dec 4]; 180:(6):273–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15012564 . doi: 10.5694/j.1326-5377.2004.tb05924.x
     [Google Scholar]
  3. Pearce N, Sunyer J, Cheng S, Chinn S, Björkstén B, Burr M, et al.  Comparison of asthma prevalence in the ISAAC and the ECRHS. ISAAC Steering Committee and the European Community Respiratory Health Survey. International Study of Asthma and Allergies in Childhood. European Respiratory Journal [Internet]. 2000 Sep [cited 2018 Dec 4]; 16:(3):420–426. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11028654 .
     [Google Scholar]
  4. Mirzaei M, Karimi M, Beheshti S, Mohammadi M. Prevalence of asthma among Middle Eastern children: A systematic review. Medical Journal of the Islamic Republic of Iran[Internet]. 2017 Jan 1 [cited 2018 Dec 4]; 31:(1):9. Available from: http://mjiri.iums.ac.ir/article-1-3243-en.html . doi: 10.18869/mjiri.31.9
     [Google Scholar]
  5. Janahi IA, Bener A, Bush A. Prevalence of asthma among Qatari schoolchildren: International study of asthma and allergies in childhood, Qatar. Pediatric Pulmonology [Internet]. 2006 Jan [cited 2018 Dec 4]; 41:(1):80–86. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16283628 .
     [Google Scholar]
  6. Al-Thani M, Al-Thani A, Alyafei S, Al-Chetachi W, Khalifa SE, Ahmed A, et al.  The prevalence and characteristics of overweight and obesity among students in Qatar. Public Health. 2018; 160::143–149. https://doi.org/10.1016/j.puhe.2018.03.020 . doi:10.1016/j.puhe.2018.03.020
     [Google Scholar]
  7. Azizpour Y, Delpisheh A, Montazeri Z, Sayehmiri K, Darabi B. Effect of childhood BMI on asthma: A systematic review and meta-analysis of case–control studies. BMC Pediatrics [Internet]. 2018 Dec 26 [cited 2018 Dec 4]; 18:(1):143. Available from: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-018-1093-z . doi: 10.1186/s12887-018-1093-z
     [Google Scholar]
  8. Visness CM, London SJ, Daniels JL, Kaufman JS, Yeatts KB, Siega-Riz AM, et al.  Association of childhood obesity with atopic and nonatopic asthma: Results from the National Health and Nutrition Examination Survey 1999–2006. Journal of Asthma[Internet]. 2010Sep 16 [cited 2018 Dec 4]; 47:(7):822–829. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20707763 . doi: 10.3109/02770903.2010.489388
     [Google Scholar]
  9. World Health Organization. Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. WHO Technical Report Series 894 [Internet].Geneva: World Health Organization; 2000. [cited 2018 Dec 5] Available from: http://www.ncbi.nlm.nih.gov/pubmed/11234459 .
  10. Scholtens S, Wijga AH, Seidell JC, Brunekreef B, de Jongste JC, Gehring U, et al.  Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age. Journal of Allergy and Clinical Immunology [Internet]. 2009 Jun [cited 2018 Dec 4]; 123:(6):1312–1318.e2. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19409606 . doi: 10.1016/j.jaci.2009.02.029
     [Google Scholar]
  11. Van Gysel D, Govaere E, Verhamme K, Doli E, De Baets F. Body mass index in Belgian schoolchildren and its relationship with sensitization and allergic symptoms. Pediatric Allergy and Immunology [Internet]. 2009May [cited 2018 Dec 4]; 20:(3):246–253. Available from: http://doi.wiley.com/10.1111/j.1399-3038.2008.00774.x . doi: 10.1111/j.1399-3038.2008.00774.x
     [Google Scholar]
  12. Visness CM, London SJ, Daniels JL, Kaufman JS, Yeatts KB, Siega-Riz A-M, et al.  Association of obesity with IgE levels and allergy symptoms in children and adolescents: Results from the National Health and Nutrition Examination Survey 2005–2006. Journal of Allergy and Clinical Immunology [Internet]. 2009May [cited 2018 Dec 4]; 123:(5):1163–1169.e1–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19230960 . doi: 10.1016/j.jaci.2008.12.1126
     [Google Scholar]
  13. Mai X-M, Almqvist C, Nilsson L, Wickman M. Birth anthropometric measures, body mass index and allergic diseases in a birth cohort study (BAMSE). Archives of Disease in Childhood [Internet]. 2007 Oct 1 [cited 2018 Dec 4]; 92:(10):881–886. Available from: http://adc.bmj.com/cgi/doi/10.1136/adc.2006.110692 . doi: 10.1136/adc.2006.110692
     [Google Scholar]
  14. Magnusson JO, Kull I, Mai XM, Wickman M, Bergström A. Early childhood overweight and asthma and allergic sensitization at 8 years of age. Pediatrics [Internet]. 2012 Jan 1 [cited 2018 Dec 4]; 129:(1):70–76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22184644 . doi: 10.1542/peds.2010-2953
     [Google Scholar]
  15. To T, Vydykhan TN, Dell S, Tassoudji M, Harris JK. Is obesity associated with asthma in young children? Journal of Pediatrics[Internet]. 2004 Feb [cited 2018 Dec 4]; 144:(2):162–168. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0022347603006760 . doi: 10.1016/j.jpeds.2003.09.047
     [Google Scholar]
  16. Bäcklund AB, Perzanowski MS, Platts-Mills T, Sandström T, Lundbäck B, Rönmark E. Asthma during the primary school ages – Prevalence, remission and the impact of allergic sensitization. Allergy [Internet]. 2006 May [cited 2018 Dec 4]; 61:(5):549–555. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16629783 .
     [Google Scholar]
  17. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, et al.  Leptin regulates proinflammatory immune responses. FASEB Journal [Internet]. 1998 Jan [cited 2018 Dec 4]; 12:(1):57–65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9438411 .
     [Google Scholar]
  18. Mai X-M, Böttcher MF, Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatric Allergy and Immunology. 2004 Dec [cited 2018 Dec 4]; 15:(6):523–530. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15610366 .
     [Google Scholar]
  19. Magnus MC, Stigum H, Håberg SE, Nafstad P, London SJ, Nystad W. Peak weight and height velocity to age 36 months and asthma development: The Norwegian Mother and Child Cohort Study. PLoS One [Internet]. 2015 Jan 30 [cited 2018 Dec 4]; 10:(1):e0116362. Available from: https://dx.plos.org/10.1371/journal.pone.0116362 . doi: 10.1371/journal.pone.0116362
     [Google Scholar]
  20. Kaplan TA, Montana E. Exercise-induced bronchospasm in nonasthmatic obese children. Clinical Pediatrics. 1993 Apr 2 [cited 2018 Dec 4]; 32:(4):220–225. Available from: http://journals.sagepub.com/doi/10.1177/000992289303200407 . doi: 10.1177/000992289303200407
     [Google Scholar]
  21. del Río-Navarro B, Cisneros-Rivero M, Berber-Eslava A, Espínola-Reyna G, Sienra-Monge J. Exercise induced bronchospasm in asthmatic and non-asthmatic obese children. Allergologia et Immunopathologia[Internet]. [cited 2018 Dec 4]2000; 28:(1):5–11. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10757851 .
     [Google Scholar]
  22. Vázquez-Nava F, Morales Romero J, Córdova-Fernandez JA, Saldívar-González AH, Vázquez-Rodríguez CF, Barrientos-Gómez Mdel C, et al.  Association between obesity and asthma in preschool Mexican children. Scientific World Journal. 2010 Jul 7 [cited 2018 Dec 4]; 10::1339–1346. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20623094 . doi: 10.1100/tsw.2010.134
     [Google Scholar]
  23. Sharma G. Asthma in children: Symptoms, treatment, attacks and medications [Internet]. [cited 2018 Dec 4].Available from: https://www.emedicinehealth.com/asthma_in_children/article_em.htm#what_are_symptoms_of_childhood_asthma .
  24. Morosco G, Kiley J. National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): Guidelines for the diagnosis and management of asthma – Summary report 2007. Journal of Allergy and Clinical Immunology [Internet]. 2007 Nov [cited 2018 Dec 4]; 120:(5 Suppl):S94–S138. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0091674907018404 .
     [Google Scholar]
  25. Salpeter SR, Ormiston TM, Salpeter EE. Meta-analysis: Respiratory tolerance to regular beta2-agonist use in patients with asthma. Annals of Internal Medicine [Internet]. 2004 May 18 [cited 2018 Dec 4]; 140:(10):802–813. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15148067 . doi: 10.7326/0003-4819-140-10-200405180-00010
     [Google Scholar]
  26. Rachelefsky G. Treating exacerbations of asthma in children: The role of systemic corticosteroids. Pediatrics [Internet]. 2003 Aug [cited 2018 Dec 4]; 112:(2):382–397. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12897291 .
     [Google Scholar]
  27. Kwon HL, Ortiz B, Swaner R, Shoemaker K, Jean-Louis B, Northridge ME, et al.  Childhood asthma and extreme values of body mass index: The Harlem Children’s Zone Asthma Initiative. Journal of Urban Health. 2006; 83:(3):421–433. Available from: http://link.springer.com/10.1007/s11524-006-9050-9 . doi: 10.1007/s11524-006-9050-9
     [Google Scholar]
  28. Reilly JJ. Pediatric Mini Review: Diagnostic accuracy of the BMI for age in paediatrics. International Journal of Obesity. 2006; 30::595–597. https://doi.org/10.1038/sj.ijo.0803301 . doi: 10.1038/sj.ijo.0803301
     [Google Scholar]
  29. de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bulletin of the World Health Organization. 2007; 85::660–667. doi: 10.2471/BLT.07.043497
     [Google Scholar]
  30. Cole TJ, Lobstein T. Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatric Obesity. 2012; 7:(4):284–294. doi: 10.1111/j.2047-6310.2012.00064.x
     [Google Scholar]
  31. Kuczmarski RJ, Ogden, CL, Grummer-Strawn LM, Flegal KM, Guo SS, Wei R, et al. CDC growth charts: United States. Advance data from vital and health statistics; no. 314. Hyattsville, MD: National Center for Health Statistics; 2000.
     [Google Scholar]
  32. Ekström S, Magnusson J, Kull I, Andersson N, Bottai M, Besharat Pour M, et al.  Body mass index development and asthma throughout childhood. American Journal of Epidemiology [Internet]. 2017 Jul 15 [cited 2018 Dec 4]; 186:(2):255–263. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28838063 . doi: 10.1093/aje/kwx081
     [Google Scholar]
  33. Byberg KK, Mikalsen IB, Eide GE, Forman MR, Júlíusson PB, Øymar K. The associations between weight-related anthropometrics during childhood and lung function in late childhood: A retrospective cohort study. BMC Pulmonary Medicine [Internet]. 2018Jan 19 [cited 2018 Dec 4]; 18:(1):10. Available from: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-017-0567-3 . doi: 10.1186/s12890-017-0567-3
     [Google Scholar]
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Association between body mass index (BMI) percentile and asthma in children of 5–12 years old: A case–control study using electronic medical records in Primary Health Care Corporation, Qatar 2016–2017
QScience Connect 2019, 6 (2019); https://doi.org/10.5339/connect.2019.6
/content/journals/10.5339/connect.2019.6
/content/journals/10.5339/connect.2019.6
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  • Article Type: Research Article
Keyword(s): body mass index, Childhood asthma, obesity, overweight, primary health care and Qatar

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