1887
  1. Home
  2. A-Z Publications
  3. Qatar Medical Journal
  4. Volume 2010, Issue 2
  5. Article
Volume 2010, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

A prospective cohort study of 18 males aged 19–45 years with chronic renal failure attending the Ibn Sina Teaching Hospital, Mosul for Hemodialysis (HD) between March 2007 and March 2008 assessed the oxidative stress, antioxidant status, serum urea and serum creatinine before and after hemodialysis and following subsequent supplementation with oral Vitamin E. Blood samples collected before starting hemodialysis, after three weeks of twice-weekly dialysis, and then after three weeks of oral vitamin E (400 i.u/day) showed significant decreases of total antioxidant status (TAS) after HD but a significant increase of TAS after Vitamin E therapy; a non-significant increase of lipid peroxidation indicator (serum malondialdehyde; MDA) after HD alone but a significant decrease of MDA after Vitamin E therapy; a highly significant decrease of serum urea after HD and a highly significant increase of serum urea after Vitamin E therapy; a highly significant decrease of serum creatinine after HD and a highly significant increase of serum creatinine after Vitamin E therapy; a highly significant decrease of serum uric acid after HD and a highly significant increase of serum uric acid after Vitamin E therapy. There were non-significant correlations between TAS and MDA, uric acid, serum urea and serum creatinine after HD and after Vitamin E therapy. It is concluded that in patients with chronic renal failure oxidative stress is further exacerbated, as shown by decreased TAS and increased MDA although serum uric acid is not the sole contributor. Vitamin E supplementation in such patients after HD does not enhance renal function but it decreases the oxidative stress by decreasing MDA and enhancing antioxidant body status by increasing significantly TAS and serum uric acid.

© 2010 Al Youzbaki, Thanoon, Mustafa, Al Hayali, licensee Bloomsbury Qatar Foundation Journals.
Loading

Article metrics loading...

/content/journals/10.5339/qmj.2010.2.13
2010-12-01
2024-04-20
Loading full text...

Full text loading...

References

  1. Report from the National Kidney Foundation Task Force on Cardiovascular Disease, 1998 (www.kidney.org/professionals/pysfile/cardiointro.cfm)..
  2. Rohrmoser MM, Mayor G. Reactive oxygen species and glumerular injury. Kidney Blood Pres Res. 1996; 19::263–269.
     [Google Scholar]
  3. Baliga R, Ueda N, Walker PD. Oxidant mechanisms in toxic acute renal failure. Am J Kidney Dis. 1997; 29::465–577.
     [Google Scholar]
  4. Riemersma RA. Epidemiology and the role of an tioxidant preventing coronary heat disease: a brief overview. Proceeding of Nutrition Society. 1994; 53::59–65.
     [Google Scholar]
  5. Packer L. Interactions among antioxidants in health and disease: Vitamin E and its redox cycle. Proc Soc Exp Biol Mid. 1992; 200::271–276.
     [Google Scholar]
  6. Southorn PA, Powis G. Free radicals in medicine I. Chemical nature and biologic reactions. Myo Clin Proc. 1988; 63::381–389.
     [Google Scholar]
  7. Jacob RA. The integrated antioxidant system. Nut Res. 1995; 15::755–766.
     [Google Scholar]
  8. Smart D, McCusker CM, Lamont JV, Fitz Gerald SP, Lapin A, Temml C. Reference value for various antioxidant parameters in a normal working population. . Proceeding of the XVI International Congress of Clinical Chemistry. London 1996;.
  9. Marcus R, Coulston AM. The vitamins: Introduction and fat soluble vitamins. In: Oilman AGLimbird LE, eds. Goodman and Gillman's. The pharmacological basis of therapeutics. 9th ed. USA: McGraw Hill 1995:p.1547.
     [Google Scholar]
  10. Stahl W, Sies H. Antioxidant defense: Vitamin E and C and carotinoids. Diabetes. 1997; 46::S14–S18.
     [Google Scholar]
  11. Gambhir JK, Lali P, Jain AK. Correlation between blood antioxidant level and lipid peroxidation in rheumatoid arthritis. Clin Biochem. 1997; 30::351–355.
     [Google Scholar]
  12. Clermont G, Lecour S, Lahet J. Alteration in plasma an tioxidant capacities in chronic renal failure and hemodialysis patients: A possible explanation for the increased cardiovascular risks in these patients. Cardiovasc Res. 2000 Aug 18; 47:3:618–623.
     [Google Scholar]
  13. Hultqvist M, Hegbront J, Nilsson-Thorell C, et al., Plasma concentrations of vitamin C, vitamin E and /or malondialdehyde as markers of oxygen free radical production during hemodialysis. Clin Nephrol. 1997 Jan; 47:1:37–46.
     [Google Scholar]
  14. Buege JA, Aust SD. Microsomal lipid peroxidation. In: Methods in Enzymology. Biomembranes. Part C: Biological oxidations Microsomal, Cytochrome P-450, and other hemoprotein systems. Fleischers, Packer L editors. San Francisco London. 1978; 52::302–306.
     [Google Scholar]
  15. Dursun E, Ozben T, Suleymanlar G, Dursun B, Yakupogly G. Effect of hemodialysis on the oxidative stress and antioxidants. Clin Chem Lab Med. 2002 Oct; 40:10:1009–1013.
     [Google Scholar]
  16. Abdel-Naeem NM, Kandell NF, El-Shamaa AA, Harba TM, Abdel-Hady AA. Biocompatible dialysis membranes and oxidative stress in patients with end-stage renal disease on maintenance hemodialysis. J Egypt Soc Parasitol. 2005 Dec; 35:3 Suppl:1173–1197.
     [Google Scholar]
  17. Mimic-Oka J, Simic T, Djukanovic L, Reljic Z, Davicevic Z. Alteration in plasma antioxidant capacity in various degrees of chronic renal failure. Clin Nephrol. 1999 Apr; 51:4:233–241.
     [Google Scholar]
  18. Samouilidou E, Grapsa E. Effect of dialysis on plasma total antioxidant capacity and lipid peroxidation products in patients with end-stage renal failure. Blood Purif. 2003; 21:3:209–212.
     [Google Scholar]
  19. Jackson P, Loughrey CM, Lightbody JH, McNamee PT, Young IS. Effect of hemodialysis on total antioxidant capacity and serum antioxidants in patients with chronic renal failure. Clin Chem. 1995 Aug; 41:8 Pt 1:1135–1138.
     [Google Scholar]
  20. Zwolmska D, Graeszczak W, Kilis-Pstrusinska K, Szprynger K, Szczepanska M. Lipid peroxidation and antioxidant enzymes in children with chronic renal failure. Pediatr Nephrol. 2004 Aug; 19:8:888–892.
     [Google Scholar]
  21. Ha TK, Sattar N, Talwar D. Abnormal antioxidant vitamin and carotenoid status in chronic renal failure. Q J Med. 1996; 89::765–769.
     [Google Scholar]
  22. Daschner M, Lenhartz H, Botticher D. Influence of dialysis on plasma lipid peroxidation products and antioxidant levels. Kidney Jnt. 1996 Oct; 50:4:1268–1272.
     [Google Scholar]
  23. Mircescu G, Capusa C, Stoian I, Vargolici B, Barbulescu C, Ursea N. Global assessment of serum antioxidant status in hemodialysis patients. J Nephrol. 2005 Sep-Oct; 18:5:599–605.
     [Google Scholar]
  24. Diplock AT. Safety of antioxidant vitamins and Rcarotene. Am J Clin Nutr. 1995; 62:Suppl:510–516.
     [Google Scholar]
  25. Suha YA, Yurtkuran M, Dilek K, et al., The effect of vitamin E therapy on plasma and erythrocyte lipid peroxidation in chronic hemdialysis patients. Clin Chem Acta. 1989; 185::109–112.
     [Google Scholar]
  26. Galli F, Floridi AG, Floridi A, Buoncristiani U. Accumulation of vitamin E metabolites in the blood of renal failure patients. Clin Nutr. 2004 Apr; 23:2:205–212.
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2010.2.13
Loading
  • Article Type: Research Article
Keyword(s): Chronic renal failure, hemodialysis, malondialdehyde, oxidative, stress, total antioxidant status and uric acid

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error