oa Muscle-specific Expression of Erry in the Myostatin Null Background Leads to the Development of Hypertrophied Oxidative Muscle

A fundamental concept of skeletal muscle proposes an inverse relation between oxidative metabolic potential of muscle fiber and its cross-sectional area (CSA). The dystrophin-glycoprotein complex (DGC) play a vital role in transducing the contractile force of myofibrils as well as mitigating contraction-induced damage. Aims: Investigate the relationships between muscle fibersize and oxidative capacity, and muscle fiber-phenotype with DGC. Methods: We obtained the hypertrophic-highly oxidative phosphorylation model by over-expressing the estrogen-related receptor gamma (Erry) on the Myostatin (a potential inhibitor of skeletal muscle enlargement) null (Mtn ^-/-) background mice. Results: Superimposition of Erry on the Mtn^-/- background results in hypertrophic muscle that displays a high oxidative capacity (Mtn^-/-/Erry^Tg/+ ). Conclusion: The study revealed firstly that the prospect of producing muscle fibers that have large CSA are associated with high oxidative capacity. Secondly, the expression of sarcolemma DGC proteins would be massively regulated by the metabolic phenotype of muscle fibers.