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Abstract

Abstract

The aim of the present study was to comparatively evaluate genomic damage and cellular death in exfoliated oral mucosa cells and peripheral blood from car painters. A total of 24 car painters and 19 health controls (non-exposed individuals) were included in this setting. Individuals had epithelial cells from cheek mucosa (left and right side) mechanically exfoliated, placed in fixative and dropped in clean slides which were checked for the above nuclear phenotypes. A total of 5uL from peripheral blood was collected for the single cell gel (comet) assay. The results pointed out significant statistical differences (p<0.05) of micronucleated oral mucosa cells from car painters. In addition, DNA damage was detected in peripheral blood cells by single cell gel (comet) assay. Nevertheless, exposure to car paints did not cause an increase in other nuclear alterations closely related to cytotoxicity such as karrhyorexis, pyknosis and karyolysis in buccal mucosa cells.

In summary, the results of the present study suggest that car painters comprise a high risk group as paints can induce genotoxic and mutagenic effects in peripheral blood and oral mucosa cells, respectively.

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/content/papers/10.5339/qproc.2012.mutagens.3.72
2012-03-01
2019-11-17
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http://instance.metastore.ingenta.com/content/papers/10.5339/qproc.2012.mutagens.3.72
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  • Received: 15 May 2012
  • Accepted: 15 May 2012
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