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Volume 2022, Issue 3
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Background: Rituximab is used as second-line therapy in patients with immune thrombocytopenic purpura (ITP) who do not respond to first-line management. The response rate for Rituximab is variable in different populations ranging from 30% to 90%. The adverse effects of rituximab in patients with ITP range from infusion site reactions to the reactivation of hepatitis B virus and progressive multifocal leukoencephalopathy and interpopulation variation.

Methods: We conducted a single-center, retrospective study in Qatar's National Center for Cancer Care & Research. The study included patients with chronic refractory ITP who received rituximab as second-line therapy. Descriptive and summary statistics were used to describe the sociodemographic parameters of the study cohort.

Results: Of the 41 patients with chronic ITP, 26 were Arabs, 12 were Asians, and 3 were of other ethnicities. Rituximab was associated with an overall response rate of 80.4%. Arabic patients had the highest clinical response (84.6%) among the ethnicities with the lowest adverse effects (11.5%). Asians had a response rate of 66.6%, and adverse effects were seen in 16.7% of the patients.

Conclusions: In chronic refractory ITP, rituximab appears to have a better clinical response in the Arabic population with minimal toxicity than in other ethnicities.

© 2022 Ata, Yousaf, Zahir, Babiker, Ali Farooqi, Al Hiyari, Al Bozom, Mohamed, Nashwan, Yassin, licensee HBKU Press.
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2022-07-07
2024-04-20
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http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2022.22
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Efficacy and safety of rituximab as second-line therapy in immune thrombocytopenic purpura based on ethnicity: A descriptive study among the Arabic population
Qatar Medical Journal 2022, 22 (2022); https://doi.org/10.5339/qmj.2022.22
/content/journals/10.5339/qmj.2022.22
/content/journals/10.5339/qmj.2022.22
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  • Article Type: Research Article
Keyword(s): Ethnicity, Immune thrombocytopenic purpura, ITP and Rituximab

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