Abstract
A patient with Philadelphia chromosome positive chronic myeloid leukemia (CML) being treated with INF-a conceived during treatment which continued for the whole course of her pregnancy. A female infant was born at 40th week of gestation and was found to have a platelet count of 56 x 109/L which returned to normal after two weeks.
A literature review of similar cases showed no abnormalities in the infants of mothers receiving INF-a during pregnancy. The safety of INF-a during pregnancy requires further study before its routine use during pregnancy can be recommended.
© 2000 Kakil I.R., et. al., licensee Bloomsbury Qatar Foundation Journals.
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2000-06-01
2024-03-29
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References
-
Maria RB. Normal full term pregnancy in a patient with CML treated with INF-a. Am. J. Hematology. 1991; 37::66.
[Google Scholar]
-
Jose J, Manuel C. Normal Pregnancy in a patient with Essential Thrombo-cytopenia treated with INF-a. Am J Hematology. 1992; 40::80.
[Google Scholar]
-
Maria R. INF-a therapy during pregnancy in chronic myeloid leukaemia and Hairy Cell Leukemia. Brit J Haematology. 1992; 81::167–167.
[Google Scholar]
-
Huggston J, Adransson M. Two cases of CML treated with INF-a during second and third trimester of pregnancy. Eur J Hematology. 1996; 57::101–102.
[Google Scholar]
-
Sakata H. INF-a therapy for Multiple Myeloma during pregnancy. Am J. Obstet.- Gynecol. Jan. 1995; 172::217–219.
[Google Scholar]
-
Peter M, Moshe T, Quesada JR. Immune thrombocytopenia following INF-a in patients with cancer. JAMA. 1985; 254::1353–1354.
[Google Scholar]
-
Kanfer EJ, McCarthy DM. Immune thrombocytopenia and INF-a. Br.MedJ. 1988; 297::1613.
[Google Scholar]
-
Vianelli N, Gugliotta l, Tura S, Rizzo N. INF-a, -2a treatment in a pregnant woman with essential thrombocytosis. Blood. 1994 Feb; 83:3:874–875.
[Google Scholar]
-
Lipton JH, Derzko CM, Cartis J. INF-a and pregnancy in a patient with CML Hematol-Oncol. 1996 Sep; 14:3:119–122.
[Google Scholar]
-
Delage R, Demers C, Cantin G, Roy J. Treatment of essential thrombocytosis during pregnancy with INF-a. Obstet-Gynecol. 1996 May; 87:5 pt 2:814–817.
[Google Scholar]
-
Kuroiwa M, Gundo H, Ashida K, Kamimmara T. INF-a therapy for Chronic Myelogenous Leukemia during pregnancy. Am. J. Hematol. 1998 Sep; 59:1:101–102.
[Google Scholar]
-
Ruggiero G, Anderiana A, Zampino R. Normal pregnancy under inadvertant INF-a therapy for Chronic Hepatitis C. J. Hepatol. 1996 May; 24:5:646.
[Google Scholar]
-
Moncosa A, Andita FV, Leonandi J, Scanderi M. INF-a 2a and pregnancy. Report of a case of Chronic Inflammatory Demyelinating Polyneuropathy. Acta Obstet-Gynecol-Scand. 1998 Sept; 77:8:869–870.
[Google Scholar]
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