Volume 2000, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426


A patient with Philadelphia chromosome positive chronic myeloid leukemia (CML) being treated with INF-a conceived during treatment which continued for the whole course of her pregnancy. A female infant was born at 40th week of gestation and was found to have a platelet count of 56 x 109/L which returned to normal after two weeks.

A literature review of similar cases showed no abnormalities in the infants of mothers receiving INF-a during pregnancy. The safety of INF-a during pregnancy requires further study before its routine use during pregnancy can be recommended.


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  1. Maria RB. Normal full term pregnancy in a patient with CML treated with INF-a. Am. J. Hematology. 1991; 37::66.
    [Google Scholar]
  2. Jose J, Manuel C. Normal Pregnancy in a patient with Essential Thrombo-cytopenia treated with INF-a. Am J Hematology. 1992; 40::80.
    [Google Scholar]
  3. Maria R. INF-a therapy during pregnancy in chronic myeloid leukaemia and Hairy Cell Leukemia. Brit J Haematology. 1992; 81::167167.
    [Google Scholar]
  4. Huggston J, Adransson M. Two cases of CML treated with INF-a during second and third trimester of pregnancy. Eur J Hematology. 1996; 57::101102.
    [Google Scholar]
  5. Sakata H. INF-a therapy for Multiple Myeloma during pregnancy. Am J. Obstet.- Gynecol. Jan. 1995; 172::217219.
    [Google Scholar]
  6. Peter M, Moshe T, Quesada JR. Immune thrombocytopenia following INF-a in patients with cancer. JAMA. 1985; 254::13531354.
    [Google Scholar]
  7. Kanfer EJ, McCarthy DM. Immune thrombocytopenia and INF-a. Br.MedJ. 1988; 297::1613.
    [Google Scholar]
  8. Vianelli N, Gugliotta l, Tura S, Rizzo N. INF-a, -2a treatment in a pregnant woman with essential thrombocytosis. Blood. 1994 Feb; 83:3:874875.
    [Google Scholar]
  9. Lipton JH, Derzko CM, Cartis J. INF-a and pregnancy in a patient with CML Hematol-Oncol. 1996 Sep; 14:3:119122.
    [Google Scholar]
  10. Delage R, Demers C, Cantin G, Roy J. Treatment of essential thrombocytosis during pregnancy with INF-a. Obstet-Gynecol. 1996 May; 87:5 pt 2:814817.
    [Google Scholar]
  11. Kuroiwa M, Gundo H, Ashida K, Kamimmara T. INF-a therapy for Chronic Myelogenous Leukemia during pregnancy. Am. J. Hematol. 1998 Sep; 59:1:101102.
    [Google Scholar]
  12. Ruggiero G, Anderiana A, Zampino R. Normal pregnancy under inadvertant INF-a therapy for Chronic Hepatitis C. J. Hepatol. 1996 May; 24:5:646.
    [Google Scholar]
  13. Moncosa A, Andita FV, Leonandi J, Scanderi M. INF-a 2a and pregnancy. Report of a case of Chronic Inflammatory Demyelinating Polyneuropathy. Acta Obstet-Gynecol-Scand. 1998 Sept; 77:8:869870.
    [Google Scholar]
  • Article Type: Case Report
Keyword(s): Alfa Interferon (INF-a)Chronic Myeloid LeukemiaPregnancy and Thrombocytopenia
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