1887
Volume 2014, Issue 4
  • ISSN: 2305-7823
  • E-ISSN:

Abstract

Genetic disorders are not equally distributed over the geography of the Arab region. While a number of disorders have a wide geographical presence encompassing 10 or more Arab countries, almost half of these disorders occur in a single Arab country or population. Nearly, one-third of the genetic disorders in Arabs result from congenital malformations and chromosomal abnormalities, which are also responsible for a significant proportion of neonatal and perinatal deaths in Arab populations. Strikingly, about two-thirds of these diseases in Arab patients follow an autosomal recessive mode of inheritance. High fertility rates together with increased consanguineous marriages, generally noticed in Arab populations, tend to increase the rates of genetic and congenital abnormalities. Many of the nearly 500 genes studied in Arab people revealed striking spectra of heterogeneity with many novel and rare mutations causing large arrays of clinical outcomes. In this review we provided an overview of Arab gene geography, and various genetic abnormalities in Arab populations, including disorders of blood, metabolic, circulatory and neoplasm, and also discussed their associated molecules or genes responsible for the cause of these disorders. Although studying Arab-specific genetic disorders resulted in a high value knowledge base, approximately 35% of genetic diseases in Arabs do not have a defined molecular etiology. This is a clear indication that comprehensive research is required in this area to understand the molecular pathologies causing diseases in Arab populations.

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2015-02-11
2019-10-19
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References

  1. [2]. Hunter-Zinck   H., , Musharoff   S., , Salit   J., , Al-Ali   KA., , Chouchane   L., , Gohar   A., , Matthews   R., , Butler   MW., , Fuller   J., , Hackett   NR., , Crystal   RG., , Clark   AG. . Population genetic structure of the people of Qatar. . Am J Hum Genet.   2010; ;87: 1 : 17– 25 .
    [Google Scholar]
  2. [3]. Liu   H., , Prugnolle   F., , Manica   A., , Balloux   F. . A geographically explicit genetic model of worldwide human-settlement history. . Am J Hum Genet.   2006; ;79: 2 : 230– 237 .
    [Google Scholar]
  3. [4]. Ferembach   D. . Human remains from the epipaleolithic period in the Taforalt grotto in eastern Morocco. . C R Hebd Seances Acad Sci.   1959; ;248: 24 : 3465– 3467 .
    [Google Scholar]
  4. [5]. Bouzouggar   A., , Barton   N., , Vanhaeren   M., , d'Errico   F., , Collcutt   S., , Higham   T., , Hodge   E., , Parfitt   S., , Rhodes   E., , Schwenninger   JL., , Stringer   C., , Turner   E., , Ward   S., , Moutmir   A., , Stambouli   A. . 82,000-year-old shell beads from North Africa and implications for the origins of modern human behavior. . Proc Natl Acad Sci U S A . 2007; ;104: 24 : 9964– 9969 .
    [Google Scholar]
  5. [6]. Relethford   JH. . Genetic evidence and the modern human origins debate. . Heredity.   2008; ;100: 6 : 555– 563 .
    [Google Scholar]
  6. [7]. Fernandes   V., , Alshamali   F., , Alves   M., , Costa   MD., , Pereira   JB., , Silva   NM., , Cherni   L., , Harich   N., , Cerny   V., , Soares   P., , Richards   MB., , Pereira   L. . The Arabian cradle: Mitochondrial relicts of the first steps along the southern route out of Africa. . Am J Hum Genet.   2012; ;90: 2 : 347– 355 .
    [Google Scholar]
  7. [8]. Bailey   GN., , Flemming   NC., , King   GCP., , Lambeck   K., , Momber   G., , Moran   LJ., , Al-Sharekh   A., , Vita-Finzi   C. . Coastlines, submerged landscapes, and human evolution: The Red Sea Basin and the Farasan Islands. . J Island Coastal Archaeol.   2007; ;2: : 127– 160 .
    [Google Scholar]
  8. [9]. Cerný   V., , Mulligan   CJ., , Rídl   J., , Zaloudková   M., , Edens   CM., , Hájek   M., , Pereira   L. . Regional differences in the distribution of the sub-Saharan, West Eurasian, and South Asian mtDNA lineages in Yemen. . Am J Phys Anthropol.   2008; ;136: 2 : 128– 137 .
    [Google Scholar]
  9. [10]. Abu-Amero   KK., , Hellani   A., , González   AM., , Larruga   JM., , Cabrera   VM., , Underhill   PA. . Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions. . BMC Genet.   2009; ;10: : 59 .
    [Google Scholar]
  10. [11]. Cadenas   AM., , Zhivotovsky   LA., , Cavalli-Sforza   LL., , Underhill   PA., , Herrera   RJ. . Y-chromosome diversity characterizes the Gulf of Oman. . Eur J Hum Genet.   2008; ;16: 3 : 374– 386 .
    [Google Scholar]
  11. [12]. Cann   RL., , Stoneking   M., , Wilson   AC. . Mitochondrial DNA and human evolution. . Nature.   1987; ;325: 6099 : 31– 36 .
    [Google Scholar]
  12. [13]. Ingman   M., , Kaessmann   H., , Pääbo   S., , Gyllensten   U. . Mitochondrial genome variation and the origin of modern humans. . Nature.   2000; ;408: 6813 : 708– 713 .
    [Google Scholar]
  13. [14]. Luis   JR., , Rowold   DJ., , Regueiro   M., , Caeiro   B., , Cinnioğlu   C., , Roseman   C., , Underhill   PA., , Cavalli-Sforza   LL., , Herrera   RJ. . The Levant versus the Horn of Africa: Evidence for bidirectional corridors of human migrations. . Am J Hum Genet.   2004; ;74: 3 : 532– 544 .
    [Google Scholar]
  14. [15]. Pérez-Miranda   AM., , Alfonso-Sánchez   MA., , Peña   JA., , Herrera   RJ. . Qatari DNA variation at a crossroad of human migrations. . Hum Hered.   2006; ;61: 2 : 67– 79 .
    [Google Scholar]
  15. [16]. Ferri   G., , Tofanelli   S., , Alù   M., , Taglioli   L., , Radheshi   E., , Corradini   B., , Paoli   G., , Capelli   C., , Beduschi   G. . Y-STR variation in Albanian populations: Implications on the match probabilities and the genetic legacy of the minority claiming an Egyptian descent. . Int J Legal Med.   2010; ;124: 5 : 363– 370 .
    [Google Scholar]
  16. [17]. González-Pérez   E., , Esteban   E., , Via   M., , Gayà-Vidal   M., , Athanasiadis   G., , Dugoujon   JM., , Luna   F., , Mesa   MS., , Fuster   V., , Kandil   M., , Harich   N., , Bissar-Tadmouri   N., , Saetta   A., , Moral   P. . Population relationships in the Mediterranean revealed by autosomal genetic data (Alu and Alu/STR compound systems). . Am J Phys Anthropol.   2010; ;141: 3 : 430– 439 .
    [Google Scholar]
  17. [18]. Moorjani   P., , Patterson   N., , Hirschhorn   JN., , Keinan   A., , Hao   L., , Atzmon   G., , Burns   E., , Ostrer   H., , Price   AL., , Reich   D. . The history of African gene flow into Southern Europeans, Levantines, and Jews. . PLoS Genet.   2011; ;7: 4 : e1001373 .
    [Google Scholar]
  18. [19]. Ke   Y., , Su   B., , Song   X., , Lu   D., , Chen   L., , Li   H., , Qi   C., , Marzuki   S., , Deka   R., , Underhill   P., , Xiao   C., , Shriver   M., , Lell   J., , Wallace   D., , Wells   RS., , Seielstad   M., , Oefner   P., , Zhu   D., , Jin   J., , Huang   W., , Chakraborty   R., , Chen   Z., , Jin   L. . African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes. . Science.   2001; ;292: 5519 : 1151– 1153 .
    [Google Scholar]
  19. [20]. Maca-Meyer   N., , González   AM., , Larruga   JM., , Flores   C., , Cabrera   VM. . Major genomic mitochondrial lineages delineate early human expansions. . BMC Genet.   2001; ;2: : 13 .
    [Google Scholar]
  20. [21]. Underhill   PA., , Passarino   G., , Lin   AA., , Shen   P., , Mirazón Lahr   M., , Foley   RA., , Oefner   PJ., , Cavalli-Sforza   LL. . The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. . Ann Hum Genet.   2001; ;65: Pt 1 : 43– 62 .
    [Google Scholar]
  21. [22]. Lahr   MM., , Field   JS. . Assessment of the southern dispersal: GIS-based analyses of potential routes at oxygen isotopic stage 4. . J World Prehistory.   2005; ;19: : 1– 45 .
    [Google Scholar]
  22. [23]. Manni   F., , Leonardi   P., , Barakat   A., , Rouba   H., , Heyer   E., , Klintschar   M., , McElreavey   K., , Quintana-Murci   L. . Y-chromosome analysis in Egypt suggests a genetic regional continuity in Northeastern Africa. . Hum Biol.   2002; ;74: 5 : 645– 658 .
    [Google Scholar]
  23. [24]. Ennafaa   H., , Cabrera   VM., , Abu-Amero   KK., , González   AM., , Amor   MB., , Bouhaha   R., , Dzimiri   N., , Elgaaïed   AB., , Larruga   JM. . Mitochondrial DNA haplogroup H structure in North Africa. . BMC Genet.   2009; ;10: : 8 .
    [Google Scholar]
  24. [25]. Rowold   DJ., , Luis   JR., , Terreros   MC., , Herrera   RJ. . Mitochondrial DNA geneflow indicates preferred usage of the Levant Corridor over the Horn of Africa passageway. . J Hum Genet.   2007; ;52: 5 : 436– 447 .
    [Google Scholar]
  25. [26]. Saleheen   D., , Frossard   PM. . The cradle of the ΔF508 mutation. . J Ayub Med Coll Abbottabad.   2008; ;20: 4 : 157– 160 .
    [Google Scholar]
  26. [27]. Obeid   T., , Tadmouri   GO. . Initial results of a pilot Arab human variome project. . In: Tadmouri   GO., Taleb Al Ali   M., Al Khaja   N. , eds. Genetic Disorders in the Arab World: Qatar . Dubai, United Arab Emirates: : Centre for Arab Genomic Studies;   2012; .
    [Google Scholar]
  27. [28]. Rose   JI. . New light on human prehistory in the Arabo-Persian Gulf Oasis. . Curr Anthropol.   2010; ;51: : 849– 883 .
    [Google Scholar]
  28. [29]. Al-Zahery   N., , Pala   M., , Battaglia   V., , Grugni   V., , Hamod   MA., , Hooshiar Kashani   B., , Olivieri   A., , Torroni   A., , Santachiara-Benerecetti   AS., , Semino   O. . In search of the genetic footprints of Sumerians: A survey of Y-chromosome and mtDNA variation in the Marsh Arabs of Iraq. . BMC Evol Biol.   2011; ;11: : 288 .
    [Google Scholar]
  29. [30]. Grmek   MD. . Malaria in the eastern Mediterranean in prehistory and antiquity. . Parassitologia.   1994; ;36: : 1– 6 .
    [Google Scholar]
  30. [31]. de Zulueta   J. . Malaria and ecosystems: From prehistory to posteradication. . Parassitologia.   1994; ;36: : 7– 15 .
    [Google Scholar]
  31. [32]. Joy   DA., , Feng   X., , Mu   J., , Furuya   T., , Chotivanich   K., , Krettli   AU., , Ho   M., , Wang   A., , White   NJ., , Suh   E., , Beerli   P., , Su   XZ. . Early origin and recent expansion of Plasmodium falciparum. . Science.   2003; ;300: 5617 : 318– 321 .
    [Google Scholar]
  32. [33]. Angel   JL. . Porotic hyperostosis, anemias, malarias, and marshes in the prehistoric Eastern Mediterranean. . Science.   1966; ;153: : 760– 763 .
    [Google Scholar]
  33. [34]. Carter   R., , Mendis   KN. . Evolutionary and historical aspects of the burden of malaria. . Clin Microbiol Rev.   2002; ;15: : 564– 594 .
    [Google Scholar]
  34. [35]. Kwiatkowski   DP. . How malaria has affected the human genome and what human genetics can teach us about malaria. . Am J Hum Genet.   2005; ;77: : 171– 192 .
    [Google Scholar]
  35. [36]. Ziskind   B., , Halioua   B. . La tuberculose en ancienne Egypte. . Rev Mal Respir.   2007; ;24: 10 : 1277– 1283 .
    [Google Scholar]
  36. [37]. Karlsson   EK., , Kwiatkowski   DP., , Sabeti   PC. . Natural selection and infectious disease in human populations. . Nat Rev Genet.   2014; ;15: 6 : 379– 393 .
    [Google Scholar]
  37. [38]. Poolman   EM., , Galvani   AP. . Evaluating candidate agents of selective pressure for cystic fibrosis. . J R Soc Interface.   2007; ;4: 12 : 91– 98 .
    [Google Scholar]
  38. [39]. Stiehm   ER. . Disease versus disease: How one disease may ameliorate another. . Pediatrics.   2006; ;117: 1 : 184– 191 .
    [Google Scholar]
  39. [40]. Abu-Amero   KK., , Larruga   JM., , Cabrera   VM., , González   AM. . Mitochondrial DNA structure in the Arabian Peninsula. . BMC Evol Biol.   2008; ;8: : 45 .
    [Google Scholar]
  40. [41]. Bar-Yosef   O. . The Natufian culture in the Levant, threshold to the origins of agriculture. . Evol Anthropol.   1998; ;6: : 159– 177 .
    [Google Scholar]
  41. [42]. AlShamali   F., , Pereira   L., , Budowle   B., , Poloni   ES., , Currat   M. . Local population structure in Arabian Peninsula revealed by Y-STR diversity. . Hum Hered.   2009; ;68: 1 : 45– 54 .
    [Google Scholar]
  42. [43]. Fu   W., , O'Connor   TD., , Jun   G., , Kang   HM., , Abecasis   G., , Leal   SM., , Gabriel   S., , Rieder   MJ., , Altshuler   D., , Shendure   J., , Nickerson   DA., , Bamshad   MJ., , NHLBI Exome Sequencing Project., , Akey   JM. . Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. . Nature . 2013; ;493: 7431 : 216– 220 .
    [Google Scholar]
  43. [44]. Beech   CM., , Liyanarachchi   S., , Shah   NP., , Sturm   AC., , Sadiq   MF., , de la Chapelle   A., , Tanner   SM. . Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities. . Orphanet J Rare Dis.   2011; ;6: : 74 .
    [Google Scholar]
  44. [45]. Terreros   MC., , Rowold   DJ., , Mirabal   S., , Herrera   RJ. . Mitochondrial DNA and Y-chromosomal stratification in Iran: Relationship between Iran and the Arabian Peninsula. . J Hum Genet.   2011; ;56: 3 : 235– 246 .
    [Google Scholar]
  45. [46]. Arredi   B., , Poloni   ES., , Paracchini   S., , Zerjal   T., , Fathallah   DM., , Makrelouf   M., , Pascali   VL., , Novelletto   A., , Tyler-Smith   C. . A predominantly neolithic origin for Y-chromosomal DNA variation in North Africa. . Am J Hum Genet.   2004; ;75: 2 : 338– 345 .
    [Google Scholar]
  46. [47]. Kujanová   M., , Pereira   L., , Fernandes   V., , Pereira   JB., , Cerný   V. . Near eastern neolithic genetic input in a small oasis of the Egyptian Western Desert. . Am J Phys Anthropol.   2009; ;140: 2 : 336– 346 .
    [Google Scholar]
  47. [48]. Lucotte   G., , Aouizérate   A., , Berriche   S. . Y-chromosome DNA haplotypes in north African populations. . Hum Biol.   2000; ;72: 3 : 473– 480 .
    [Google Scholar]
  48. [49]. Lucotte   G., , Mercier   G. . Brief communication: Y-chromosome haplotypes in Egypt. . Am J Phys Anthropol.   2003; ;121: 1 : 63– 66 .
    [Google Scholar]
  49. [50]. Irish   JD. . The Iberomaurusian enigma: North African progenitor or dead end?.   J Hum Evol.   2000; ;39: : 393– 410 .
    [Google Scholar]
  50. [51]. Beech   M., , Cuttler   R., , Moscrop   D., , Kallweit   H., , Martin   J. . New evidence for the Neolithic settlement of Marawah Island, Abu Dhabi, United Arab Emirates. . PSAS.   2005; ;35: : 37– 56 .
    [Google Scholar]
  51. [52]. Bahri   R., , El Moncer   W., , Al-Batayneh   K., , Sadiq   M., , Esteban   E., , Moral   P., , Chaabani   H. . Genetic differentiation and origin of the Jordanian population: An analysis of Alu insertion polymorphisms. . Genet Test Mol Biomarkers.   2012; ;16: 5 : 324– 329 .
    [Google Scholar]
  52. [53]. Omberg   L., , Salit   J., , Hackett   N., , Fuller   J., , Matthew   R., , Chouchane   L., , Rodriguez-Flores   JL., , Bustamante   C., , Crystal   RG., , Mezey   JG. . Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations. . BMC Genet.   2012; ;13: : 49 .
    [Google Scholar]
  53. [54]. Garcia-Bertrand   R., , Simms   TM., , Cadenas   AM., , Herrera   RJ. . United Arab Emirates: Phylogenetic relationships and ancestral populations. . Gene.   2014; ;533: 1 : 411– 419 .
    [Google Scholar]
  54. [55]. Walter   H., , Matsumoto   H., , De Stefano   GF. . Gm and Km allotypes in four Sardinian population samples. . Am J Phys Anthropol.   1991; ;86: 1 : 45– 50 .
    [Google Scholar]
  55. [56]. Tadmouri   GO., , Garguier   N., , Demont   J., , Perrin   P., , Başak   AN. . History and origin of beta-thalassemia in Turkey: Sequence haplotype diversity of beta-globin genes. . Hum Biol.   2001; ;73: 5 : 661– 674 .
    [Google Scholar]
  56. [57]. Gérard   N., , Berriche   S., , Aouizérate   A., , Diéterlen   F., , Lucotte   G. . North African Berber and Arab influences in the western Mediterranean revealed by Y-chromosome DNA haplotypes. . Hum Biol.   2006; ;78: 3 : 307– 316 .
    [Google Scholar]
  57. [58]. Zalloua   PA., , Xue   Y., , Khalife   J., , Makhoul   N., , Debiane   L., , Platt   DE., , Royyuru   AK., , Herrera   RJ., , Hernanz   DF., , Blue-Smith   J., , Wells   RS., , Comas   D., , Bertranpetit   J., , Tyler-Smith   C., , Genographic Consortium. . Y-chromosomal diversity in Lebanon is structured by recent historical events. . Am J Hum Genet.   2008a; ;82: : 873– 882 .
    [Google Scholar]
  58. [59]. Loirat   F., , Hazout   S., , Lucotte   G. . G542X as a probable Phoenician cystic fibrosis mutation. . Hum Biol.   1997; ;69: 3 : 419– 425 .
    [Google Scholar]
  59. [60]. Zalloua   PA., , Platt   DE., , El Sibai   M., , Khalife   J., , Makhoul   N., , Haber   M., , Xue   Y., , Izaabel   H., , Bosch   E., , Adams   SM., , Arroyo   E., , López-Parra   AM., , Aler   M., , Picornell   A., , Ramon   M., , Jobling   MA., , Comas   D., , Bertranpetit   J., , Wells   RS., , Tyler-Smith   C., , Genographic Consortium. . Identifying genetic traces of historical expansions: Phoenician footprints in the Mediterranean. . Am J Hum Genet.   2008b; ;83: : 633– 642 .
    [Google Scholar]
  60. [61]. Zahed   L., , Demont   J., , Bouhass   R., , Trabuchet   G., , Hänni   C., , Zalloua   P., , Perrin   P. . Origin and history of the IVS-I-110 and codon 39 beta-thalassemia mutations in the Lebanese population. . Hum Biol.   2002; ;74: : 837– 847 .
    [Google Scholar]
  61. [62]. Fattoum   S., , Abbes   S. . Some data on the epidemiology of hemoglobinopathies in Tunisia. . Hemoglobin.   1985; ;9: : 423– 429 .
    [Google Scholar]
  62. [63]. Ben Abdeladhim   A., , Aïssaoui   B., , Boussen   M., , Homozygous   O. . Arab hemoglobinopathy in a Tunisian family. Apropos of a case. . Tunis Med.   1987; ;65: : 571– 574 .
    [Google Scholar]
  63. [64]. Labie   D., , Elion   J., , Beldjord   C. . On the diversity of beta-globin mutations, a reflection of recent historic events in Israel. . Am J Hum Genet.   1994; ;55: 6 : 1284– 1285 .
    [Google Scholar]
  64. [65]. Salem   AH., , Badr   FM., , Gaballah   MF., , Pääbo   S. . The genetics of traditional living: Y-chromosomal and mitochondrial lineages in the Sinai Peninsula. . Am J Hum Genet.   1996; ;59: 3 : 741– 743 .
    [Google Scholar]
  65. [66]. Gutala   R., , Carvalho-Silva   DR., , Jin   L., , Yngvadottir   B., , Avadhanula   V., , Nanne   K., , Singh   L., , Chakraborty   R., , Tyler-Smith   C. . A shared Y-chromosomal heritage between Muslims and Hindus in India. . Hum Genet.   2006; ;120: 4 : 543– 551 .
    [Google Scholar]
  66. [67]. Gomes   MP., , da Costa   MG., , Braga   LB., , Cordeiro-Ferreira   NT., , Loi   A., , Pirastu   M., , Cao   A. . Beta-thalassemia mutations in the Portuguese population. . Hum Genet.   1988; ;78: 1 : 13– 15 .
    [Google Scholar]
  67. [68]. Jassim   N., , Merghoub   T., , Pascaud   O., , al Mukharraq   H., , Ducrocq   R., , Labie   D., , Elion   J., , Krishnamoorthy   R., , Arrayed   SA. . Molecular basis of beta-thalassemia in Bahrain: An epicenter for a Middle East specific mutation. . Ann N Y Acad Sci.   1998; ;850: : 407– 409 .
    [Google Scholar]
  68. [69]. Al-Ali   AK., , Al-Ateeq   S., , Imamwerdi   BW., , Al-Sowayan   S., , Al-Madan   M., , Al-Muhanna   F., , Bashaweri   L., , Qaw   F. . Molecular Bases of beta-thalassemia in the Eastern Province of Saudi Arabia. . J Biomed Biotechnol.   2005a; ;2005: 4 : 322– 325 .
    [Google Scholar]
  69. [70]. Purdey   M. . The pathogenesis of Machado Joseph Disease: A high manganese/low magnesium initiated CAG expansion mutation in susceptible genotypes?.   J Am Coll Nutr.   2004; ;23: 6 : 715S– 729S .
    [Google Scholar]
  70. [71]. Mittal   U., , Srivastava   AK., , Jain   S., , Jain   S., , Mukerji   M. . Founder haplotype for Machado-Joseph disease in the Indian population: Novel insights from history and polymorphism studies. . Arch Neurol.   2005; ;62: 4 : 637– 640 .
    [Google Scholar]
  71. [72]. Haj Khelil   A., , Laradi   S., , Miled   A., , Tadmouri   GO., , Ben Chibani   J., , Perrin   P. . Clinical and molecular aspects of haemoglobinopathies in Tunisia. . Clin Chim Acta.   2004; ;340: : 127– 137 .
    [Google Scholar]
  72. [73]. Loueslati   BY., , Cherni   L., , Khodjet-Elkhil   H., , Ennafaa   H., , Pereira   L., , Amorim   A., , Ben Ayed   F., , Ben Ammar Elgaaied   A. . Islands inside an island: Reproductive isolates on Jerba island. . Am J Hum Biol.   2006; ;18: 1 : 149– 153 .
    [Google Scholar]
  73. [74]. González   AM., , Karadsheh   N., , Maca-Meyer   N., , Flores   C., , Cabrera   VM., , Larruga   JM. . Mitochondrial DNA variation in Jordanians and their genetic relationship to other Middle East populations. . Ann Hum Biol.   2008; ;35: 2 : 212– 231 .
    [Google Scholar]
  74. [75]. Jalal   SD., , Al-Allawi   NA., , Bayat   N., , Imanian   H., , Najmabadi   H., , Faraj   A. . β-Thalassemia mutations in the Kurdish population of northeastern Iraq. . Hemoglobin.   2010; ;34: 5 : 469– 476 .
    [Google Scholar]
  75. [76]. Tadmouri   GO., , Nair   P., , Obeid   T., , Al Ali   MT., , Al Khaja   N., , Hamamy   HA. . Consanguinity and reproductive health among Arabs. . Reprod Health.   2009; ;6: : 17 .
    [Google Scholar]
  76. [77]. AlKuraya   FS. . Autozygome decoded. . Genet Med.   2010; ;12: 12 : 765– 771 .
    [Google Scholar]
  77. [78]. Fadhlaoui-Zid   K., , Martinez-Cruz   B., , Khodjet-el-khil   H., , Mendizabal   I., , Benammar-Elgaaied   A., , Comas   D. . Genetic structure of Tunisian ethnic groups revealed by paternal lineages. . Am J Phys Anthropol.   2011; ;146: 2 : 271– 280 .
    [Google Scholar]
  78. [79]. Tadmouri   GO. . Genetic disorders in Arabs. . In: Tadmouri   GO., Taleb Al Ali   M., Al Khaja   N. , eds. Genetic Disorders in the Arab World: Qatar . Dubai, United Arab Emirates: : Centre for Arab Genomic Studies;   2012; .
    [Google Scholar]
  79. [80]. Daoud   BB., , Mosbehi   I., , Préhu   C., , Chaouachi   D., , Hafsia   R., , Abbes   S. . Molecular characterization of erythrocyte glucose-6-phosphate dehydrogenase deficiency in Tunisia. . Pathol Biol (Paris) . 2008; ;56: 5 : 260– 267 .
    [Google Scholar]
  80. [81]. Nafa   K., , Reghis   A., , Osmani   N., , Baghli   L., , Benabadji   M., , Kaplan   JC., , Vulliamy   TJ., , Luzzatto   L. . G6PD Aures: A new mutation (48 Ile‐‐>Thr) causing mild G6PD deficiency is associated with favism. . Hum Mol Genet.   1993; ;2: 1 : 81– 82 .
    [Google Scholar]
  81. [82]. Niazi   GA., , Adeyokunnu   A., , Westwood   B., , Beutler   E. . Neonatal jaundice in Saudi newborns with G6PD Aures. . Ann Trop Paediatr.   1996; ;16: 1 : 33– 37 .
    [Google Scholar]
  82. [83]. Beutler   E. . Glucose-6-phosphate dehydrogenase deficiency. . In: Williams   WJ., Beutler   E., Erslev   AS., Lichtman   MA. , eds. Haematology . New York: : McGraw-Hill;   1991; .
    [Google Scholar]
  83. [84]. Bayoumi   RA., , Nur-E-Kamal   MS., , Tadayyon   M., , Mohamed   KK., , Mahboob   BH., , Qureshi   MM., , Lakhani   MS., , Awaad   MO., , Kaeda   J., , Vulliamy   TJ., , Luzzatto   L. . Molecular characterization of erythrocyte glucose-6-phosphate dehydrogenase deficiency in Al-Ain District. . United Arab Emirates. Hum Hered.   1996; ;46: 3 : 136– 141 .
    [Google Scholar]
  84. [85]. AlFadhli   S., , Kaaba   S., , Elshafey   A., , Salim   M., , AlAwadi   A., , Bastaki   L. . Molecular characterization of glucose-6-phosphate dehydrogenase gene defect in the Kuwaiti population. . Arch Pathol Lab Med.   2005; ;129: 9 : 1144– 1147 .
    [Google Scholar]
  85. [86]. El-Hazmi   MA., , Al-Swailem   AR., , Al-Faleh   FZ., , Warsy   AS. . Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase deficiency in the Saudi population. . Hum Hered.   1986; ;36: 1 : 45– 49 .
    [Google Scholar]
  86. [87]. El-Hazmi   MA., , Warsy   AS. . Frequency of glucose-6-phosphate dehydrogenase variants and deficiency in Arabia. . Gene Geogr.   1990; ;4: 1 : 15– 19 .
    [Google Scholar]
  87. [88]. Karadsheh   NS., , Moses   L., , Ismail   SI., , Devaney   JM., , Hoffman   E. . Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Jordan. . Haematologica.   2005; ;90: 12 : 1693– 1694 .
    [Google Scholar]
  88. [89]. Al-Allawi   N., , Eissa   AA., , Jubrael   JM., , Jamal   SA., , Hamamy   H. . Prevalence and molecular characterization of Glucose-6-Phosphate dehydrogenase deficient variants among the Kurdish population of Northern Iraq. . BMC Blood Disord.   2010; ;10: : 6 .
    [Google Scholar]
  89. [90]. Kurdi-Haidar   B., , Mason   PJ., , Berrebi   A., , Ankra-Badu   G., , al-Ali   A., , Oppenheim   A., , Luzzatto   L. . Origin and spread of the glucose-6-phosphate dehydrogenase variant (G6PD-Mediterranean) in the Middle East. . Am J Hum Genet.   1990; ;47: 6 : 1013– 1019 .
    [Google Scholar]
  90. [91]. Aburawi   EH. . Call for multinational studies of the epidemiology of congenital heart disease in the Arab World. . Ibnosina J Med BS . 2013; .
    [Google Scholar]
  91. [92]. Yehya   A., , Souki   R., , Bitar   F., , Nemer   G. . Differential duplication of an intronic region in the NFATC1 gene in patients with congenital heart disease. . Genome.   2006; ;49: 9 : 1092– 1098 .
    [Google Scholar]
  92. [93]. Aqrabawi   HE. . Facial cleft and associated anomalies: Incidence among infants at a Jordanian medical centre. . East Mediterr Health J.   2008; ;14: 2 : 356– 359 .
    [Google Scholar]
  93. [94]. Tas   S. . Strong association of a single nucleotide substitution in the 3'-untranslated region of the apolipoprotein-CIII gene with common hypertriglyceridemia in Arabs. . Clin Chem.   1989; ;35: 2 : 256– 259 .
    [Google Scholar]
  94. [95]. Hussain   SS., , Buraiki   J., , Dzimiri   N., , Butt   AI., , Vencer   L., , Basco   MC., , Khan   B. . Polymorphism in apoprotein-CIII gene and coronary heart disease. . Ann Saudi Med.   1999; ;19: 3 : 201– 205 .
    [Google Scholar]
  95. [96]. Abu-Amero   KK., , Wyngaard   CA., , Dzimiri   N. . Association of the platelet glycoprotein receptor IIIa (PlA1/PlA1) genotype with coronary artery disease in Arabs. . Blood Coagul Fibrinolysis.   2004; ;15: 1 : 77– 79 .
    [Google Scholar]
  96. [97]. Al-Ali   AK., , Al-Muhana   FA., , Larbi   EB., , Abdulmohsen   MF., , Al-Sultan   AI., , Al-Maden   MS., , Al-Ateeq   SA. . Frequency of methylenetetrahydrofolate reductase C677T polymorphism in patients with cardiovascular disease in Eastern Saudi Arabia. . Saudi Med J.   2005b; ;26: 12 : 1886– 1888 .
    [Google Scholar]
  97. [98]. Abu-Amero   KK., , Al-Boudari   OM., , Mohamed   GH., , Dzimiri   N. . T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking. . BMC Med Genet.   2006; ;7: : 38 .
    [Google Scholar]
  98. [99]. Abu-Amero   KK., , Wyngaard   CA., , Al-Boudari   OM., , Kambouris   M., , Dzimiri   N. . Lack of association of lipoprotein lipase gene polymorphisms with coronary artery disease in the Saudi Arab population. . Arch Pathol Lab Med.   2003a; ;127: 5 : 597– 600 .
    [Google Scholar]
  99. [100]. Johansen   K., , Dunn   B., , Tan   JC., , Kwaasi   AA., , Skotnicki   A., , Skotnicki   M. . Coronary artery disease and apolipoprotein A-I/C-III gene polymorphism: A study of Saudi Arabians. . Clin Genet.   1991; ;39: 1 : 1– 5 .
    [Google Scholar]
  100. [101]. Dzimiri   N., , Basco   C., , Moorji   A., , Meyer   BF. . Angiotensin-converting enzyme polymorphism and the risk of coronary heart disease in the Saudi male population. . Arch Pathol Lab Med.   2000; ;124: 4 : 531– 534 .
    [Google Scholar]
  101. [102]. Abu-Amero   KK., , Al-Boudari   OM., , Mohamed   GH., , Dzimiri   N. . Beta 3 adrenergic receptor Trp64Arg polymorphism and manifestation of coronary artery disease in Arabs. . Hum Biol.   2005; ;77: 6 : 795– 802 .
    [Google Scholar]
  102. [103]. Cagatay   P., , Susleyici-Duman   B., , Ciftci   C. . Lipoprotein lipase gene PvuII polymorphism serum lipids and risk for coronary artery disease: Meta-analysis. . Dis Markers.   2007; ;23: 3 : 161– 166 .
    [Google Scholar]
  103. [104]. Abu-Amero   KK., , Wyngaard   CA., , Dzimiri   N. . Prevalence and role of methylenetetrahydrofolate reductase 677 C‐‐>T and 1298 A‐‐>C polymorphisms in coronary artery disease in Arabs. . Arch Pathol Lab Med.   2003b; ;127: 10 : 1349– 1352 .
    [Google Scholar]
  104. [105]. Malouf   J., , Alam   S., , Kanj   H., , Mufarrij   A., , Der Kaloustian   VM. . Hypergonadotropic hypogonadism with congestive cardiomyopathy: An autosomal-recessive disorder?.   Am J Med Genet.   1985; ;20: 3 : 483– 489 .
    [Google Scholar]
  105. [106]. El-Menyar   AA., , Bener   A., , Numan   MT., , Morcos   S., , Taha   RY., , Al-Suwaidi   J. . Epidemiology of idiopathic cardiomyopathy in Qatar during 1996-2003. . Med Princ Pract.   2006; ;15: 1 : 56– 61 .
    [Google Scholar]
  106. [107]. Al Fadley   F., , Al Manea   W., , Nykanen   DG., , Al Fadley   A., , Bulbul   Z., , Al Halees   Z. . Severe tortuosity and stenosis of the systemic, pulmonary and coronary vessels in 12 patients with similar phenotypic features: A new syndrome?.   Cardiol Young.   2000; ;10: 6 : 582– 589 .
    [Google Scholar]
  107. [108]. Coucke   PJ., , Wessels   MW., , Van Acker   P., , Gardella   R., , Barlati   S., , Willems   PJ., , Colombi   M., , De Paepe   A. . Homozygosity mapping of a gene for arterial tortuosity syndrome to chromosome 20q13. . J Med Genet.   2003; ;40: 10 : 747– 751 .
    [Google Scholar]
  108. [109]. Faiyaz-Ul-Haque   M., , Zaidi   SH., , Al-Sanna   N., , Alswaid   A., , Momenah   T., , Kaya   N., , Al-Dayel   F., , Bouhoaigah   I., , Saliem   M., , Tsui   LC., , Teebi   AS. . A novel missense and a recurrent mutation in SLC2A10 gene of patients affected with arterial tortuosity syndrome. . Atherosclerosis.   2009; ;203: 2 : 466– 471 .
    [Google Scholar]
  109. [110]. Bhuiyan   ZA., , Momenah   TS., , Amin   AS., , Al-Khadra   AS., , Alders   M., , Wilde   AA., , Mannens   MM. . An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome. . Prog Biophys Mol Biol.   2008; ;98: 2-3 : 319– 327 .
    [Google Scholar]
  110. [111]. Stuhrmann   M., , Bukhari   IA., , El-Harith   el-HA. . Naxos disease in an Arab family is not caused by the Pk2157del2 mutation. Evidence for exclusion of the plakoglobin gene. . Saudi Med J.   2004; ;25: 10 : 1449– 1452 .
    [Google Scholar]
  111. [112]. Tadmouri   GO., , Nair   P. . Cancers in Arab populations: Concise notes. . Hamdan Medical J.   2012; ;5: 1 : 79– 82 .
    [Google Scholar]
  112. [113]. Polyak   K. . Molecular alterations in ductal carcinoma in situ of the breast. . Curr Opin Oncol.   2002; ;14: 1 : 92– 96 .
    [Google Scholar]
  113. [114]. Ayad   E., , Francis   I., , Peston   D., , Shousha   S. . Triple negative, basal cell type and EGFR positive invasive breast carcinoma in Kuwaiti and British patients. . Breast J.   2009; ;15: 1 : 109– 111 .
    [Google Scholar]
  114. [115]. Rouba   A., , Kaisi   N., , Al-Chaty   E., , Badin   R., , Pals   G., , Young   C., , Worsham   MJ. . Patterns of allelic loss at the BRCA1 locus in Arabic women with breast cancer. . Int J Mol Med.   2000; ;6: 5 : 565– 569 .
    [Google Scholar]
  115. [116]. Tazzite   A., , Jouhadi   H., , Nadifi   S., , Aretini   P., , Falaschi   E., , Collavoli   A., , Benider   A., , Caligo   MA. . BRCA1 and BRCA2 germline mutations in Moroccan breast/ovarian cancer families: Novel mutations and unclassified variants. . Gynecol Oncol.   2012; ;125: 3 : 687– 692 .
    [Google Scholar]
  116. [117]. Uhrhammer   N., , Abdelouahab   A., , Lafarge   L., , Feillel   V., , Ben Dib   A., , Bignon   YJ. . BRCA1 mutations in Algerian breast cancer patients: High frequency in young, sporadic cases. . Int J Med Sci.   2008; ;5: 4 : 197– 202 .
    [Google Scholar]
  117. [118]. Troudi   W., , Uhrhammer   N., , Romdhane   KB., , Sibille   C., , Amor   MB., , Khodjet El Khil   H., , Jalabert   T., , Mahfoudh   W., , Chouchane   L., , Ayed   FB., , Bignon   YJ., , Elgaaied   AB. . Complete mutation screening and haplotype characterization of BRCA1 gene in Tunisian patients with familial breast cancer. . Cancer Biomark.   2008; ;4: 1 : 11– 18 .
    [Google Scholar]
  118. [119]. Mahfoudh   W., , Bouaouina   N., , Ahmed   SB., , Gabbouj   S., , Shan   J., , Mathew   R., , Uhrhammer   N., , Bignon   YJ., , Troudi   W., , Elgaaied   AB., , Hassen   E., , Chouchane   L. . Hereditary breast cancer in Middle Eastern and North African (MENA) populations: Identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population. . Mol Biol Rep.   2012; ;39: 2 : 1037– 1046 .
    [Google Scholar]
  119. [120]. Chouchane   L., , Boussen   H., , Sastry   KS. . Breast cancer in Arab populations: Molecular characteristics and disease management implications. . Lancet Oncol.   2013; ;14: 10 : e417– e424 .
    [Google Scholar]
  120. [121]. Kadouri   L., , Bercovich   D., , Elimelech   A., , Lerer   I., , Sagi   M., , Glusman   G., , Shochat   C., , Korem   S., , Hamburger   T., , Nissan   A., , Abu-Halaf   N., , Badrriyah   M., , Abeliovich   D., , Peretz   T. . A novel BRCA-1 mutation in Arab kindred from east Jerusalem with breast and ovarian cancer. . BMC Cancer.   2007; ;7: : 14 .
    [Google Scholar]
  121. [122]. Jalkh   N., , Nassar-Slaba   J., , Chouery   E., , Salem   N., , Uhrchammer   N., , Golmard   L., , Stoppa-Lyonnet   D., , Bignon   YJ., , Mégarbané   A. . Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon. . Hered Cancer Clin Pract.   2012; ;10: 1 : 7 .
    [Google Scholar]
  122. [123]. El-Harith   el-HA., , Abdel-Hadi   MS., , Steinmann   D., , Dork   T. . BRCA1 and BRCA2 mutations in breast cancer patients from Saudi Arabia. . Saudi Med J.   2002; ;23: 6 : 700– 704 .
    [Google Scholar]
  123. [124]. Riahi   A., , Kharrat   M., , Ghourabi   ME., , Khomsi   F., , Gamoudi   A., , Lariani   I., , May   AE., , Rahal   K., , Chaabouni-Bouhamed   H. . Mutation spectrum and prevalence of BRCA1 and BRCA2 genes in patients with familial and early-onset breast/ovarian cancer from Tunisia. . Clin Genet.   2013; ; , Dec 28 .
    [Google Scholar]
  124. [125]. Shatavi   SV., , Dohany   L., , Chisti   MM., , Jaiyesimi   IA., , Zakalik   D. . Unique genetic characteristics of BRCA mutation carriers in a cohort of Arab American women. . J Clin Oncol.   2013; ;31: suppl : abstr 1541 .
    [Google Scholar]
  125. [126]. Al-Qasem   AJ., , Toulimat   M., , Eldali   AM., , Tulbah   A., , Al-Yousef   N., , Al-Daihan   SK., , Al-Tassan   N., , Al-Tweigeri   T., , Aboussekhra   A. . TP53 genetic alterations in Arab breast cancer patients: Novel mutations, pattern and distribution. . Oncol Lett.   2011; ;2: 2 : 363– 369 .
    [Google Scholar]
  126. [127]. Snoussi   K., , Mahfoudh   W., , Bouaouina   N., , Ahmed   SB., , Helal   AN., , Chouchane   L. . Genetic variation in IL-8 associated with increased risk and poor prognosis of breast carcinoma. . Hum Immunol.   2006; ;67: 1-2 : 13– 21 .
    [Google Scholar]
  127. [128]. AlShatwi   AA., , Hasan   TN., , Shafi   G., , Alsaif   MA., , Al-Hazzani   AA., , Alsaif   AA. . A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population. . Fundam Clin Pharmacol.   2012; ;26: 3 : 438– 443 .
    [Google Scholar]
  128. [129]. Lajin   B., , Alhaj Sakur   A., , Ghabreau   L., , Alachkar   A. . Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women. . Tumour Biol.   2012; ;33: 4 : 1133– 1139 .
    [Google Scholar]
  129. [130]. Levine   DA., , Bogomolniy   F., , Yee   CJ., , Lash   A., , Barakat   RR., , Borgen   PI., , Boyd   J. . Frequent mutation of the PIK3CA gene in ovarian and breast cancers. . Clin Cancer Res.   2005; ;11: 8 : 2875– 2878 .
    [Google Scholar]
  130. [131]. Wang   Y., , Helland   A., , Holm   R., , Kristensen   GB., , Børresen-Dale   AL. . PIK3CA mutations in advanced ovarian carcinomas. . Hum Mutat.   2005; ;25: 3 : 322 .
    [Google Scholar]
  131. [132]. Abubaker   J., , Bavi   P., , Al-Haqawi   W., , Jehan   Z., , Munkarah   A., , Uddin   S., , Al-Kuraya   KS. . PIK3CA alterations in Middle Eastern ovarian cancers. . Mol Cancer.   2009; ;8: : 51 .
    [Google Scholar]
  132. [133]. Teebi   AS. . Genetic disorders among Arab populations . , Second Edition. . Berlin, Heidelberg, Germany: : Springer-Verlag;   2010; .
    [Google Scholar]
  133. [134]. Laarabi   FZ., , Cherkaoui Jaouad   I., , Baert-Desurmont   S., , Ouldim   K., , Ibrahimi   A., , Kanouni   N., , Frebourg   T., , Sefiani   A. . The first mutations in the MYH gene reported in Moroccan colon cancer patients. . Gene.   2012; ;496: 1 : 55– 58 .
    [Google Scholar]
  134. [135]. Aissi-Ben Moussa   S., , Moussa   A., , Lovecchio   T., , Kourda   N., , Najjar   T., , Ben Jilani   S., , El Gaaied   A., , Porchet   N., , Manai   M., , Buisine   MP. . Identification and characterization of a novel MLH1 genomic rearrangement as the cause of HNPCC in a Tunisian family: Evidence for a homologous Alu-mediated recombination. . Fam Cancer.   2009; ;8: 2 : 119– 126 .
    [Google Scholar]
  135. [136]. Bougatef   K., , Marrakchi   R., , Ouerhani   S., , Sassi   R., , Moussa   A., , Kourda   N., , Blondeau Lahely   Y., , Najjar   T., , Ben Jilani   S., , Soubrier   F., , Ben Ammar Elgaaied   A. . No evidence of the APC D1822V missense variant's pathogenicity in Tunisian patients with sporadic colorectal cancer. . Pathol Biol (Paris) . 2009; ;57: 3 : e67– e71 .
    [Google Scholar]
  136. [137]. Patael   Y., , Figer   A., , Gershoni-Baruch   R., , Papa   MZ., , Risel   S., , Shtoyerman-Chen   R., , Karasik   A., , Theodor   L., , Friedman   E. . Common origin of the I1307K APC polymorphism in Ashkenazi and non-Ashkenazi Jews. . Eur J Hum Genet.   1999; ;7: 5 : 555– 559 .
    [Google Scholar]
  137. [138]. Drucker   L., , Shpilberg   O., , Neumann   A., , Shapira   J., , Stackievicz   R., , Beyth   Y., , Yarkoni   S. . Adenomatous polyposis coli I1307K mutation in Jewish patients with different ethnicity: Prevalence and phenotype. . Cancer.   2000; ;88: 4 : 755– 760 .
    [Google Scholar]
  138. [139]. Niell   BL., , Long   JC., , Rennert   G., , Gruber   SB. . Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: Evidence of genetic drift within the Ashkenazim. . Am J Hum Genet.   2003; ;73: 6 : 1250– 1260 .
    [Google Scholar]
  139. [140]. Chan   AO., , Soliman   AS., , Zhang   Q., , Rashid   A., , Bedeir   A., , Houlihan   PS., , Mokhtar   N., , Al-Masri   N., , Ozbek   U., , Yaghan   R., , Kandilci   A., , Omar   S., , Kapran   Y., , Dizdaroglu   F., , Bondy   ML., , Amos   CI., , Issa   JP., , Levin   B., , Hamilton   SR. . Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries. . Clin Cancer Res.   2005; ;11: 23 : 8281– 8287 .
    [Google Scholar]
  140. [141]. Sfar   S., , Hassen   E., , Saad   H., , Mosbah   F., , Chouchane   L. . Association of VEGF genetic polymorphisms with prostate carcinoma risk and clinical outcome. . Cytokine.   2006; ;35: 1-2 : 21– 28 .
    [Google Scholar]
  141. [142]. Sfar   S., , Saad   H., , Mosbah   F., , Gabbouj   S., , Chouchane   L. . TSP1 and MMP9 genetic variants in sporadic prostate cancer. . Cancer Genet Cytogenet.   2007; ;172: 1 : 38– 44 .
    [Google Scholar]
  142. [143]. Al-Dayel   F., , Al-Rasheed   M., , Ibrahim   M., , Bu   R., , Bavi   P., , Abubaker   J., , Al-Jomah   N., , Mohamed   GH., , Moorji   A., , Uddin   S., , Siraj   AK., , Al-Kuraya   K. . Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population. . Leuk Lymphoma.   2008; ;49: 1 : 122– 129 .
    [Google Scholar]
  143. [144]. Siraj   AK., , Ibrahim   M., , Al-Rasheed   M., , Abubaker   J., , Bu   R., , Siddiqui   SU., , Al-Dayel   F., , Al-Sanea   O., , Al-Nuaim   A., , Uddin   S., , Al-Kuraya   K. . Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population. . BMC Med Genet.   2008; ;9: : 61 .
    [Google Scholar]
  144. [145]. Ouerhani   S., , Tebourski   F., , Slama   MR., , Marrakchi   R., , Rabeh   M., , Hassine   LB., , Ayed   M., , Elgaaïed   AB. . The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population. . Ann Hum Biol.   2006; ;33: 5-6 : 529– 535 .
    [Google Scholar]
  145. [146]. Ouerhani   S., , Oliveira   E., , Marrakchi   R., , Ben Slama   MR., , Sfaxi   M., , Ayed   M., , Chebil   M., , Amorim   A., , El Gaaied   AB., , Prata   MJ. . Methylenetetrahydrofolate reductase and methionine synthase polymorphisms and risk of bladder cancer in a Tunisian population. . Cancer Genet Cytogenet.   2007; ;176: 1 : 48– 53 .
    [Google Scholar]
  146. [147]. Ozçelik   T., , Kanaan   M., , Avraham   KB., , Yannoukakos   D., , Mégarbané   A., , Tadmouri   GO., , Middleton   L., , Romeo   G., , King   MC., , Levy-Lahad   E. . Collaborative genomics for human health and cooperation in the Mediterranean region. . Nat Genet.   2010; ;42: 8 : 641– 645 .
    [Google Scholar]
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  • Article Type: Review Article
Keyword(s): Arab populations , gene geography , genetic disorders , neolithic , neoplasms and population genetics
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