RT Journal Article SR Electronic(1) A1 Kalozoumi, Georgia A1 Yacoub, Magdi A1 Sanoudou, DespinaYR 2014 T1 MicroRNAs in heart failure: Small molecules with major impact JF Global Cardiology Science and Practice, VO 2014 IS 2 OP SP 30 DO https://doi.org/10.5339/gcsp.2014.30 PB Hamad bin Khalifa University Press (HBKU Press), SN 2305-7823, AB MicroRNAs (miRNAs) have emerged as potent modulators of mammalian gene expression, thereby broadening the spectrum of molecular mechanisms orchestrating human physiological and pathological cellular functions. Growing evidence suggests that these small non-coding RNA molecules are pivotal regulators of cardiovascular development and disease. Importantly, multiple miRNAs have been specifically implicated in the onset and progression of heart failure, thus providing a new platform for battling this multi-faceted disease. This review introduces the basic concepts of miRNA biology, describes representative examples of miRNAs associated with multiple aspects of HF pathogenesis, and explores the prognostic, diagnostic and therapeutic potential of miRNAs in the cardiology clinic., UL https://www.qscience.com/content/journals/10.5339/gcsp.2014.30