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Volume 2024, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Sixty patients with COVID-19 infection were categorized into mild and severe groups, and their immune response was analyzed using flow cytometry and complete blood count. An observed increase in immune activation parameters, notably a higher percentage of CD4 lymphocytes co-expressing CD69 and CD25 molecules, and enhanced activity of the macrophage-monocyte cell line was noted in the mild group. Although Group 2 (severe COVID) had fewer CD4 cells, significant migration and proliferation were evident, with increased CD4CD69, CD8 HLA-DR+, and CD8CD69 lymphocytes. The CD4 to CD8 ratio in Group 1 suggested potential autoimmune reactions, while Group 2 indicated potential immunosuppression from severe infection and employing immunosuppressive drugs. Additionally, Group 2 exhibited an increased neutrophil count, hinting at possible bacterial co-infection. Group 1 showed differences in CD4RO and CD8RA lymphocyte populations, implying that cellular immunity plays a role in developing efficient postinfectious immunity. This intimation suggests that vaccination might mitigate the severity of the coronavirus infection and prevent complications, including long-term COVID-19.

© 2024 Stroz, Kosiorek, Zbroch, Mikoluc, Stasiak-Barmuta, Licensee HBKU Press.
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2024-02-29
2024-04-29
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http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2024.11
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Immune response variation in mild and severe COVID-19 patients
Qatar Medical Journal 2024, 11 (2024); https://doi.org/10.5339/qmj.2024.11
/content/journals/10.5339/qmj.2024.11
/content/journals/10.5339/qmj.2024.11
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  • Article Type: Research Article
Keyword(s): cytometry, immunology, post-COVID syndrome, T-cells and vaccination

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