1887
Volume 2014, Issue 1
  • ISSN: 2305-7823
  • E-ISSN:

ملخص

Resistant hypertension is, by definition, a challenge to most physicians treating hypertension. Renal sympathetic denervation has shown promising early results in treating this condition. The SYMPLICITY HTN-3 is the most recent trial to report the effects of this technique on resistant hypertension. This review discusses this study and its surprising neutral results before ending with an overview of key lessons learned.

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References

  1. Krum H, Schlaich M, Whitbourn R, Sobotka P, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham W, Esler M. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009; 373::12751281.
    [Google الباحث العلمي]
  2. Symplicity HTN-2 Investigators , Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Böhm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010; 376::19031909.
    [Google الباحث العلمي]
  3. Howard JP, Nowbar AN, Francis DP. Size of blood pressure reduction from renal denervation: insights from meta-analysis of antihypertensive drug trials of 4121 patients with a focus on trial design: the CONVERGE report. Heart. 2013; 99::15791587.
    [Google الباحث العلمي]
  4. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K, Townsend RR, Bakris GL, SYMPLICITY HTN-3 Investigators . A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014; 370::13931401.
    [Google الباحث العلمي]
  5. De la Sierra A, Segura J, Banegas JR, Gorostidi M, de la Cruz JJ, Armario P, Oliveras A, Ruilope LM. Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring. Hypertension. 2011; 57::898902.
    [Google الباحث العلمي]
  6. Howard JP, Cole GD, Sievert H, Bhatt DL, Papademetriou V, Kandzari DE, Davies JE, Francis DP. Unintentional overestimation of an expected antihypertensive effect in drug and device trials: mechanisms and solutions. Int J Cardiol. 2014; 172::2935.
    [Google الباحث العلمي]
  7. Patel HC, di Mario C. Renal denervation for hypertension: where are we now? Br J Cardiol. 2013; 20::142147.
    [Google الباحث العلمي]
  8. Patel H, Rosen S, Lindsay A, Hayward C, Lyon A, di Mario C. Targeting the autonomic nervous system: measuring autonomic function and novel devices for heart failure management. Int J Cardiol. 2013; 170::107117.
    [Google الباحث العلمي]
  9. Patel H, Dhillon P, Mahfoud F, Lindsay A, Hayward C, Ersnt S, Lyon A, Rosen S, di Mario C. The biophysics of renal sympathetic denervation using radiofrequency energy. Clin Res Cardiol. 2013; 103::337344.
    [Google الباحث العلمي]
  10. Vaclavik J, Sedlak R, Plachy M, Navratil K, Plasek J, Jarovsky J, Vaclavik T, Husar R, Kocianova E, Taborsky M. Addition of spironolactone in patients with resistant arterial hypertension (ASPIRANT): a randomized, double blind, placebo-controlled trial. Hypertension. 2011; 57::10691075.
    [Google الباحث العلمي]
  11. Krum H, Schlaich M, Sobotka P, Bohm M, Mahfoud F, Rocha-Singh K, Katholi R, Esler M. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet. 2014; 383::622629.
    [Google الباحث العلمي]
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  • نوع المستند: Research Article
الموضوعات الرئيسية Renal denervationresistant hypertension and trial design
هذه الخانة مطلوبة
يُرجى إدخال عنوان بريد إلكتروني صالح
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