1887
  1. الرئيسية
  2. A-Z Publications
  3. Avicenna
  4. المجلد 2013, العدد 1
  5. المقالة
Volume 2013, Issue 1
  • E-ISSN: 2220-2749

ملخص

Preeclampsia is a pregnancy specific condition characterized by hypertension and proteinuria. It complicates about 10% of all pregnancies. It is a major cause of maternal and fetal morbidity and mortality. Interestingly, preeclampsia may have an impact on the health of the mother or infant, beyond the pregnancy. It is believed that several ligands and receptors of different families of growth factors have been involved in the development of preeclampsia. We performed a systematic search of PubMed including combination of terms such as preeclampsia, growth factors, treatment, vascular endothelial growth factor A, activin A, inhibin A, placental growth factor, transforming growth factor β-1, Nodal, placenta, trophoblast cells, biomarkers and detection. In this review we have summarized current knowledge on the role of growth factors in early detection and treatment of preeclampsia. Although these growth factors have significant roles in normal and complicated pregnancies, the current value of these growth factors as biomarkers, for the precise prediction of preeclampsia, has its limitation. Therefore, future studies need to be done to support some of the very promising and interesting data to develop affordable and widely available tests for early detection and treatment of preeclampsia.

© 2013 Munir, licensee Bloomsbury Qatar Foundation Journals.
Loading

جارٍ تحميل قياسات المقالة...

/content/journals/10.5339/avi.2013.4
٢٠١٣-٠٩-٠١
٢٠٢٤-٠٥-١٩
Loading full text...

Full text loading...

/deliver/fulltext/avi/2013/1/avi.2013.4.html?itemId=/content/journals/10.5339/avi.2013.4&mimeType=html&fmt=ahah

References

  1. Scazzocchio E, Figueras F. Contemporary prediction of preeclampsia. Curr Opin Obstet Gynecol. 2011; 23::65–71
     [Google الباحث العلمي]
  2. Tang LC, Kwok AC, Wong AY, Lee YY, Sun KO, So AP. Critical care in obstetrical patients: an eight-year review. Chin Med J (Engl). 1997; 110:12:936–941
     [Google الباحث العلمي]
  3. Hawfield A, Freedman BI. Pre-eclampsia: the pivotal role of the placenta in its pathophysiology and markers for early detection. Ther Adv Cardiovasc Dis. 2009; 3::65–73
     [Google الباحث العلمي]
  4. Tomsin K, Mesens T, Molenberghs G, Peeters L, Gyselaers W. Characteristics of heart, arteries, and veins in low and high cardiac output preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2013;, pii: S0301-2115(13)00146-2. doi: 10.1016/j.ejogrb.2013.03.016. [Epub ahead of print]
     [Google الباحث العلمي]
  5. Garovic VD, August P. Preeclampsia and the future risk of hypertension: the pregnant evidence. Curr Hypertens Rep. 2013; 15::114–121
     [Google الباحث العلمي]
  6. Berks D, Hoedjes M, Raat H, Duvekot JJ, Steegers EA, Habbema JD. Risk of cardiovascular disease after pre-eclampsia and the effect of lifestyle interventions: a literature-based study. BJOG. 2013; 120:8:924–931, doi: 10.1111/1471-0528.12191. Epub Mar 26, 2013
     [Google الباحث العلمي]
  7. Ghazal-Aswad S, Badrinath P, Sidky I, Safi TH, Gargash H, Abdul-Razak Y, Mirghani H. Severe acute maternal morbidity in a high-income developing multiethnic country. Matern Child Health J. 2013; 17:3:399–404
     [Google الباحث العلمي]
  8. Jido TA, Yakasai IA. Preeclampsia: a review of the evidence. Ann Afr Med. 2013; 12::75–85
     [Google الباحث العلمي]
  9. Mattar F, Sibai BM. Eclampsia. VIII. Risk factors for maternal morbidity. Am J Obstet Gynecol. 2000; 182::307–312
     [Google الباحث العلمي]
  10. Masuyama H, Nobumoto E, Segawa T, Hiramatsu Y. Severe superimposed preeclampsia with obesity, diabetes and a mild imbalance of angiogenic factors. Acta Med Okayama. 2012; 66::171–175
     [Google الباحث العلمي]
  11. Raymond D, Peterson E. A critical review of early-onset and late-onset preeclampsia. Obstet Gynecol Surv. 2011; 66::497–506
     [Google الباحث العلمي]
  12. Hasko M, Biringer K, Biskupska BK, Danko J. Selected markers in early prediction of preeclampsia. Ceska Gynekol. 2011; 76::135–139
     [Google الباحث العلمي]
  13. Maynard S, Epstein FH, Karumanchi SA. Preeclampsia and angiogenic imbalance. Annu Rev Med. 2008; 59::61–78
     [Google الباحث العلمي]
  14. Than NG, Romero R, Hillermann R, Cozzi V, Nie G, Huppertz B. Prediction of preeclampsia – a workshop report. Placenta. 2008; 29::S83–S85
     [Google الباحث العلمي]
  15. Thangaratinam S, Langenveld J, Mol BW, Khan KS. Prediction and primary prevention of pre-eclampsia. Best Pract Res Clin Obstet Gynaecol. 2011; 25::419–433
     [Google الباحث العلمي]
  16. Beaufils M. Pregnancy hypertension. Nephrol Ther. 2010; 6::200–214
     [Google الباحث العلمي]
  17. Boulanger H, Flamant M. New insights in the pathophysiology of preeclampsia and potential therapeutic implications. Nephrol Ther. 2007; 3::437–448
     [Google الباحث العلمي]
  18. Grill S, Rusterholz C, Zanetti-Dällenbach R, Tercanli S, Holzgreve W, Hahn S, Lapaire O. Potential markers of preeclampsia–a review. Reprod Biol Endocrinol. 2009; 7::70. doi: 10.1186/1477-7827-7-70
     [Google الباحث العلمي]
  19. Meads CA, Cnossen JS, Meher S, Juarez-Garcia A, ter Riet G, Duley L, Roberts TE, Mol BW, van der Post JA, Leeflang MM, Barton PM, Hyde CJ, Gupta JK, Khan KS. Methods of prediction and prevention of pre-eclampsia: systematic reviews of accuracy and effectiveness literature with economic modelling. Health Technol Assess. 2008; 12::1–270
     [Google الباحث العلمي]
  20. Goldenberg RL, McClure EM, Macguire ER, Kamath BD, Jobe AH. Lessons for low-income regions following the reduction in hypertension-related maternal mortality in high-income countries. Int J Gynaecol Obstet. 2011; 113:2:91–95
     [Google الباحث العلمي]
  21. Kuc S, Wortelboer EJ, van Rijn BB, Franx A, Visser GH, Schielen PC. Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia: a systematic review. Obstet Gynecol Surv. 2011; 66:4:225–239
     [Google الباحث العلمي]
  22. Hertig A, Liere P. New markers in preeclampsia. Clin Chim Acta. 2010; 411::1591–1595
     [Google الباحث العلمي]
  23. Papageorghiou AT, Campbell S. First trimester screening for preeclampsia. Curr Opin Obstet Gynecol. 2006; 18::594–600
     [Google الباحث العلمي]
  24. Smets EM, Visser A, Go ATJI, van Vugt JMG, Oudejans CBM. Novel biomarkers in preeclampsia. Clin Chim Acta. 2006; 364::22–32
     [Google الباحث العلمي]
  25. Maynard SE, Karumanchi SA. Angiogenic factors and preeclampsia. Semin Nephrol. 2011; 31::33–46
     [Google الباحث العلمي]
  26. Yu L, Li D, Liao QP, Yang HX, Cao B, Fu G, Ye G, Bai Y, Wang H, Cui N, Liu M, Li YX, Li J, Peng C, Wang YL. High levels of activin A detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting nodal signaling. J Clin Endocrinol Metab. 2012; 97:8:E1370–E1379
     [Google الباحث العلمي]
  27. Pijnenborg R, Robertson WB, Brosens I, Dixon G. Review article: trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals. Placenta. 1981; 2::71–91
     [Google الباحث العلمي]
  28. Pijnenborg R, Bland JM, Robertson WB, Dixon G, Brosens I. The pattern of interstitial trophoblastic invasion of the myometrium in early human pregnancy. Placenta. 1981; 2:4:303–316
     [Google الباحث العلمي]
  29. Pijnenborg R, Anthony J, Davey DA, Rees A, Tiltman A, Vercruysse L, van Assche A. Placental bed spiral arteries in the hypertensive disorders of pregnancy. Br J Obstet Gynaecol. 1991; 98:7:648–655
     [Google الباحث العلمي]
  30. Pietro L, Daher S, Rudge MV, Calderon IM, Damasceno DC, Sinzato YK, Bandeira C, Bevilacqua E. Vascular endothelial growth factor and VEGF-receptor expression in placenta of hyperglycaemic pregnant women. Placenta. 2010; 31::770–780
     [Google الباحث العلمي]
  31. Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, Blink AL, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Urinary placental growth factor and risk of preeclampsia. JAMA. 2005; 293::77–85
     [Google الباحث العلمي]
  32. Akolekar R, Zaragoza E, Poon LC, Pepes S, Nicolaides KH. Maternal serum placental growth factor at 11+0 to 13+6 weeks of gestation in the prediction of pre-eclampsia. Ultrasound Obstet Gynecol. 2008; 32::732–739
     [Google الباحث العلمي]
  33. Tossidou I, Schiffer M. TGF-beta/BMP pathways and the podocyte. Semin Nephrol. 2012; 32::368–376
     [Google الباحث العلمي]
  34. Chen Q, Chen L, Liu B, Vialli C, Stone P, Ching LM, Chamley L. The role of autocrine TGFbeta1 in endothelial cell activation induced by phagocytosis of necrotic trophoblasts: a possible role in the pathogenesis of pre-eclampsia. J Pathol. 2010; 221:1:87–95
     [Google الباحث العلمي]
  35. Walton KL, Makanji Y, Harrison CA. New insights into the mechanisms of activin action and inhibition. Mol Cell Endocrinol. 2012; 359::2–12
     [Google الباحث العلمي]
  36. Robertson DM. Inhibins and activins in blood: predictors of female reproductive health? Mol Cell Endocrinol. 2012; 359::78–84
     [Google الباحث العلمي]
  37. Morris JM, Gopaul NK, Endresen MJ, Knight M, Linton EA, Dhir S, Anggård EE, Redman CW. Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia. Br J Obstet Gynaecol. 1998; 105:11:1195–1199
     [Google الباحث العلمي]
  38. Lim JH, Kim SY, Park SY, Lee MH, Yang JH, Kim MY, Chung JH, Lee SW, Ryu HM. Soluble endoglin and transforming growth factor-beta1 in women who subsequently developed preeclampsia. Prenat Diagn. 2009; 29::471–476
     [Google الباحث العلمي]
  39. ten Dijke P, Goumans MJ, Pardali E. Endoglin in angiogenesis and vascular diseases. Angiogenesis. 2008; 11::79–89
     [Google الباحث العلمي]
  40. Munir S, Xu G, Wu Y, Yang B, Lala PK, Peng C. Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. J Biol Chem. 2004; 279::31277–31286
     [Google الباحث العلمي]
  41. Fu G, Ye G, Nadeem L, Ji L, Manchanda T, Wang Y, Zhao Y, Qiao J, Wang YL, Lye S, Yang BB, Peng C. MicroRNA-376c impairs transforming growth factor-beta and nodal signaling to promote trophoblast cell proliferation and invasion. Hypertension. 2013; 61::864–872
     [Google الباحث العلمي]
  42. Florio P, Gabbanini M, Borges LE, Bonaccorsi L, Pinzauti S, Reis FM, Boy Torres P, Rago G, Litta P, Petraglia F. Activins and related proteins in the establishment of pregnancy. Reprod Sci. 2010; 17:4:320–330
     [Google الباحث العلمي]
  43. McNeilly AS. Diagnostic applications for inhibin and activins. Mol Cell Endocrinol. 2012; 359::121–125
     [Google الباحث العلمي]
  44. Peng C, Mukai ST. Activins and their receptors in female reproduction. Biochem Cell Biol. 2000; 78::261–279
     [Google الباحث العلمي]
  45. Feizollahzadeh S, Taheripanah R, Khani M, Farokhia B, Amani D. Promoter region polymorphisms in the transforming growth factor beta-1 (TGFbeta1) gene and serum TGFbeta1 concentration in preeclamptic and control Iranian women. J Reprod Immunol. 2012; 94::216–221
     [Google الباحث العلمي]
  46. Yinon Y, Nevo O, Xu J, Many A, Rolfo A, Todros T, Post M, Caniggia I. Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3. Am J Pathol. 2008; 172:1:77–85
     [Google الباحث العلمي]
  47. Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res. 2000; 55::15–35, ; discussion 35–6
     [Google الباحث العلمي]
  48. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992; 255::989–991
     [Google الباحث العلمي]
  49. Purwosunu Y, Sekizawa A, Yoshimura S, Farina A, Wibowo N, Nakamura M, Shimizu H, Okai T. Expression of angiogenesis-related genes in the cellular component of the blood of preeclamptic women. Reprod Sci. 2009; 16::857–864
     [Google الباحث العلمي]
  50. Gerber HP, Condorelli F, Park J, Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem. 1997; 272::23659–23667
     [Google الباحث العلمي]
  51. Andraweera PH, Dekker GA, Roberts CT. The vascular endothelial growth factor family in adverse pregnancy outcomes. Hum Reprod Update. 2012; 18::436–457
     [Google الباحث العلمي]
  52. Many A, Hubel CA, Fisher SJ, Roberts JM, Zhou Y. Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia. Am J Pathol. 2000; 156::321–331
     [Google الباحث العلمي]
  53. Zhou Y, Genbacev O, Damsky CH, Fisher SJ. Oxygen regulates human cytotrophoblast differentiation and invasion: implications for endovascular invasion in normal pregnancy and in pre-eclampsia. J Reprod Immunol. 1998; 39::197–213
     [Google الباحث العلمي]
  54. Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest. 1997; 99::2152–2164
     [Google الباحث العلمي]
  55. Verdonk K, Visser W, Steegers EA, Kappers M, Danser AH, van den Meiracker AH. New insights into the pathogenesis of pre-eclampsia: the role of angiogenesis-inhibiting factors. Ned Tijdschr Geneeskd. 2011; 155::A2946
     [Google الباحث العلمي]
  56. Chaiworapongsa T, Romero R, Espinoza J, Bujold E, Mee Kim Y, Gonçalves LF, Gomez R, Edwin S. Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Young Investigator Award. Am J Obstet Gynecol. 2004; 190:6:1541–1547, ; discussion 1547–50
     [Google الباحث العلمي]
  57. Li Z, Zhang Y, Ying Ma J, Kapoun AM, Shao Q, Kerr I, Lam A, O'Young G, Sannajust F, Stathis P, Schreiner G, Karumanchi SA, Protter AA, Pollitt NS. Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia. Hypertension. 2007; 50::686–692
     [Google الباحث العلمي]
  58. De Falco S, Gigante B, Persico MG. Structure and function of placental growth factor. Trends Cardiovasc Med. 2002; 12::241–246
     [Google الباحث العلمي]
  59. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004; 350::672–683
     [Google الباحث العلمي]
  60. Poon LC, Zaragoza E, Akolekar R, Anagnostopoulos E, Nicolaides KH. Maternal serum placental growth factor (PlGF) in small for gestational age pregnancy at 11(+0) to 13(+6) weeks of gestation. Prenat Diagn. 2008; 28::1110–1115
     [Google الباحث العلمي]
  61. Sunderji S, Gaziano E, Wothe D, Rogers LC, Sibai B, Karumanchi SA, Hodges-Savola C. Automated assays for sVEGF R1 and PlGF as an aid in the diagnosis of preterm preeclampsia: a prospective clinical study. Am J Obstet Gynecol. 2010; 202::40e1–40e7
     [Google الباحث العلمي]
  62. Verlohren S, Galindo A, Schlembach D, Zeisler H, Herraiz I, Moertl MG, Pape J, Dudenhausen JW, Denk B, Stepan H. An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia. Am J Obstet Gynecol. 2010; 202::161e1–161e11
     [Google الباحث العلمي]
  63. Xu G, Zhong Y, Munir S, Yang BB, Tsang BK, Peng C. Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. J Clin Endocrinol Metab. 2004; 89::5523–5534
     [Google الباحث العلمي]
  64. Roten LT, Johnson MP, Forsmo S, Fitzpatrick E, Dyer TD, Brennecke SP, Blangero J, Moses EK, Austgulen R. Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study). Eur J Hum Genet. 2009; 17::250–257
     [Google الباحث العلمي]
  65. Fitzpatrick E, Johnson MP, Dyer TD, Forrest S, Elliott K, Blangero J, Brennecke SP, Moses EK. Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia. Mol Hum Reprod. 2009; 15::195–204
     [Google الباحث العلمي]
  66. Ma GT, Soloveva V, Tzeng SJ, Lowe LA, Pfendler KC, Iannaccone PM, Kuehn MR, Linzer DI. Nodal regulates trophoblast differentiation and placental development. Dev Biol. 2001; 236::124–135
     [Google الباحث العلمي]
  67. Guzman-Ayala M, Ben-Haim N, Beck S, Constam DB. Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. Proc Natl Acad Sci U S A. 2004; 101::15656–15660
     [Google الباحث العلمي]
  68. Nadeem L, Munir S, Fu G, Dunk C, Baczyk D, Caniggia I, Lye S, Peng C. Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am J Pathol. 2011; 178::1177–1189
     [Google الباحث العلمي]
  69. Lim JH, Kim SY, Park SY, Yang JH, Kim MY, Ryu HM. Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors. Obstet Gynecol. 2008; 111::1403–1409
     [Google الباحث العلمي]
http://instance.metastore.ingenta.com/content/journals/10.5339/avi.2013.4
Loading
Role of growth factors in preeclampsia: Early detection and treatment
Avicenna 2013, 4 (٢٠١٣); https://doi.org/10.5339/avi.2013.4
/content/journals/10.5339/avi.2013.4
/content/journals/10.5339/avi.2013.4
Loading

جارٍ تحميل البيانات والوسائط...

  • نوع المستند: Review Article
الموضوعات الرئيسية activin A, bio markers, detection, growth factors, inhibin A, Nodal, placenta, placental growth factor, preeclampsia, transforming growth factor β-1, treatment and vascular endothelial growth factor A

الأكثر اقتباسًا لهذا الشهر Most Cited RSS feed

هذه الخانة مطلوبة
يُرجى إدخال عنوان بريد إلكتروني صالح
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error